National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Id http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65268
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65268
Preferred Name

Bitolterol Mesylate

Definitions
The mesylate salt of bitolterol, a diester sympathomimetic amine with bronchodilator activity. As an ester prodrug, bitolterol is hydrolyzed by esterases to its active metabolite colterol (N-t-butylarterenol). Colterol selectively binds to and activates beta-2 adrenergic receptors in bronchiolar smooth muscle, thereby causing stimulation of adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased intracellular cAMP levels cause relaxation of bronchial smooth muscle. This increases air flow and prevents bronchospasms and may eventually lead to an improvement of airway function.
Synonyms
BITOLTEROL MESYLATE
Alpha-[tert-butylaminomethyl]-3,4- dihydroxybenzyl alcohol 3,4-di(p-toluate) Methanesulfonate
Bitolterol Mesylate
WIN 37284
Type http://www.w3.org/2002/07/owl#Class
Delete Subject Author Type Created
No notes to display
  • Loading...

Notes

Filter:
Add NCBO Web Widgets to your site for NCIT
Widget type Widget demonstration
Jump To

Type a class name from NCIT and jump to it in BioPortal

Get code
Form Autocomplete

Fill your form fields with classes from NCIT

Get code
Example 1 (start typing the class name to get its full URI)

Example 2 (get the ID for a class)

Example 3 (get the preferred name for a class)
Visualization

Display a visualization for a given class in NCIT

Get code
Tree Widget

Display a class tree with a search field for NCIT

Get code