National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Amlodipine Maleate
Synonyms

AMLODIPINE MALEATE

Amlodipine Maleate
Definitions

The maleate salt of amlodipine, a synthetic phenylpyridine vasodilator with antihypertensive and antianginal effects. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. Furthermore, decreased myocardial contractility and dilation of the main coronary and systemic arteries lead to increased blood flow and oxygen delivery to the myocardial tissue and decreases total peripheral resistance. This agent may also modulate multi-drug resistance (MDR) activity through inhibition of the p-glycoprotein efflux pump.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65230
CAS_Registry

88150-47-4
Chemical_Formula

C20H25ClN2O5.C4H4O4
code

C65230
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

FDA
DEFINITION

The maleate salt of amlodipine, a synthetic phenylpyridine vasodilator with antihypertensive and antianginal effects. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. Furthermore, decreased myocardial contractility and dilation of the main coronary and systemic arteries lead to increased blood flow and oxygen delivery to the myocardial tissue and decreases total peripheral resistance. This agent may also modulate multi-drug resistance (MDR) activity through inhibition of the p-glycoprotein efflux pump.
FDA_UNII_Code

CQ27G2BZJM
FULL_SYN

AMLODIPINE MALEATE

Amlodipine Maleate
Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61635
label

Amlodipine Maleate
Legacy Concept Name

Amlodipine_Maleate
Preferred_Name

Amlodipine Maleate
prefixIRI

Thesaurus:C65230
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0886700
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C333
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