National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Id http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C633
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C633
Preferred Name

Melphalan
Definitions
A phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells.
Synonyms
L-Sarcolysin
L-Sarcolysine
Melphalanum
Phenylalanine nitrogen mustard
Sarcoclorin
Alanine Nitrogen Mustard
L-Phenylalanine Mustard
L-sarcolysin
L-Phenylalanine mustard
p-di(chloroethyl)amino-L-phenylalanine
Phenylalanine Nitrogen Mustard
L-Sarcolysin Phenylalanine mustard
4-[bis(2-chloroethyl)amino]-L-phenylalanine
Phenylalanine Mustard
CB-3025
L-PAM
MELPHALAN
Melphalan
Sarkolysin
WR-19813
melphalan
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Type http://www.w3.org/2002/07/owl#Class

All Properties

label
Melphalan
Is_PCDC_GCT_Authorized_Value_For_Variable
Maps_To
Melphalan
Accepted_Therapeutic_Use_For
Breast cancer; neuroblastoma; palliative treatment of multiple myeloma and nonresectable epithelial ovarian carcinoma; rhabdomyosarcoma
Legacy Concept Name
Melphalan
CHEBI_ID
CHEBI:28876
NCI_Drug_Dictionary_ID
779085
Is_Value_For_GDC_Property
PDQ_Closed_Trial_Search_ID
779085
Preferred_Name
Melphalan
Display_Name
Melphalan
Semantic_Type
Amino Acid, Peptide, or Protein
Pharmacologic Substance
prefixIRI
Thesaurus:C633
DEFINITION
A phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells.
UMLS_CUI
C0025241
code
C633
Chemical_Formula
C13H18Cl2N2O2
Is_PCDC_AML_Authorized_Value_For_Variable
subClassOf
NSC Number
241286
8806
type
CAS_Registry
148-82-3
FULL_SYN
L-Sarcolysin
L-Sarcolysine
Melphalanum
Phenylalanine nitrogen mustard
Sarcoclorin
Alanine Nitrogen Mustard
L-Phenylalanine Mustard
L-sarcolysin
L-Phenylalanine mustard
p-di(chloroethyl)amino-L-phenylalanine
Phenylalanine Nitrogen Mustard
L-Sarcolysin Phenylalanine mustard
4-[bis(2-chloroethyl)amino]-L-phenylalanine
Phenylalanine Mustard
CB-3025
L-PAM
MELPHALAN
Melphalan
Sarkolysin
WR-19813
melphalan
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FDA_UNII_Code
Q41OR9510P
ALT_DEFINITION
A drug that is used to treat multiple myeloma and ovarian epithelial cancer and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called alkylating agents.
PDQ_Open_Trial_Search_ID
779085
Contributing_Source
CTRP
FDA
GDC
HemOnc
PCDC
Concept_In_Subset
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173234
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C174019
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177383
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177406
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537
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Has_Salt_Form
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