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National Cancer Institute Thesaurus
Last uploaded:
July 2, 2026
| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62072
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62072
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|---|---|
| Preferred Name | Procarbazine |
| Definitions |
A methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.
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| Synonyms |
N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine
Ibenzmethyzin
N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide
N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide
PROCARBAZINE
Benzethyzin
Procarbazine
Procarbazin
procarbazine
N-Methylhydrazine
p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label | Procarbazine
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|---|---|
| prefixIRI | Thesaurus:C62072
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| code | C62072
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| DEFINITION | A methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.
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| ALT_DEFINITION | The active ingredient in a drug that is used to treat advanced Hodgkin lymphoma and is being studied in the treatment of other types of cancer. Procarbazine blocks cells from making proteins and damages DNA. It may kill cancer cells. It is a type of antineoplastic agent and a type of alkylating agent.
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| Is_Value_For_GDC_Property | |
| Legacy Concept Name | Procarbazine_Base
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| Contributing_Source |
CTRP
FDA
GDC
HemOnc
PCDC
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| FULL_SYN |
N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine
Ibenzmethyzin
N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide
N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide
PROCARBAZINE
Benzethyzin
Procarbazine
Procarbazin
procarbazine
N-Methylhydrazine
p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide
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See less
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| Chemical_Formula | C12H19N3O
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| UMLS_CUI | C0033223
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| Maps_To | Procarbazine
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| FDA_UNII_Code | 35S93Y190K
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| Preferred_Name | Procarbazine
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| type | |
| subClassOf | |
| Display_Name | Procarbazine
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| Has_Salt_Or_Ester_Form | |
| CAS_Registry | 671-16-9
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| Concept_In_Subset |
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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