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National Cancer Institute Thesaurus
Last uploaded:
July 2, 2026
| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62028
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62028
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|---|---|
| Preferred Name | Epirubicin |
| Definitions |
A 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.
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| Synonyms |
(8S-cis)-10-((3-Amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
4'-Epidoxorubicin
4'-Epiadriamycin
Pidorubicin
3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranoside
Epidoxorubicin
4'-epi DX
EPIRUBICIN
Epi DX
Epirubicin
epirubicin
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label | Epirubicin
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|---|---|
| Maps_To | Epirubicin
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| Legacy Concept Name | Epirubicin_Base
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| CHEBI_ID | CHEBI:47898
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| Is_Value_For_GDC_Property | |
| Preferred_Name | Epirubicin
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| Display_Name | Epirubicin
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| prefixIRI | Thesaurus:C62028
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| DEFINITION | A 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.
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| UMLS_CUI | C0014582
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| code | C62028
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| Chemical_Formula | C27H29NO11
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| subClassOf | |
| type | |
| CAS_Registry | 56420-45-2
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| FULL_SYN | (8S-cis)-10-((3-Amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
4'-Epidoxorubicin
4'-Epiadriamycin
Pidorubicin
3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranoside
Epidoxorubicin
4'-epi DX
EPIRUBICIN
Epi DX
Epirubicin
epirubicin
See more
See less
|
| FDA_UNII_Code | 3Z8479ZZ5X
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| ALT_DEFINITION | A drug used together with other drugs to treat early breast cancer that has spread to lymph nodes. It is also being studied in the treatment of other types of cancer. Epirubicin is a type of anthracycline antibiotic.
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| Contributing_Source |
CTRP
FDA
GDC
HemOnc
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| Concept_In_Subset |
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| Has_Target | |
| Has_Salt_Or_Ester_Form |
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