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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61858
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61858
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|---|---|
| Preferred Name | Nateglinide |
| Definitions |
A phenylalanine derivative of the meglitinide class of agents with hypoglycemic activity. Nateglinide, compared to repaglitinide, binds with a higher affinity to the SUR1 subunit and with a faster onset of action and a shorter duration of action. This agent is metabolized by the cytochrome P450 isoenzyme CYP2C9, and, to a lesser extent, by CYP3A4. The parent drug and metabolites are mainly excreted in the urine and its half-life is about 1.5 hours.
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| Synonyms |
NATEGLINIDE
Nateglinide
Starlix
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Nateglinide
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|---|---|
| Legacy Concept Name |
Nateglinide
|
| NCI_Drug_Dictionary_ID |
775333
|
| PDQ_Closed_Trial_Search_ID |
775333
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| Preferred_Name |
Nateglinide
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| Semantic_Type |
Pharmacologic Substance
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| prefixIRI |
Thesaurus:C61858
|
| DEFINITION |
A phenylalanine derivative of the meglitinide class of agents with hypoglycemic activity. Nateglinide, compared to repaglitinide, binds with a higher affinity to the SUR1 subunit and with a faster onset of action and a shorter duration of action. This agent is metabolized by the cytochrome P450 isoenzyme CYP2C9, and, to a lesser extent, by CYP3A4. The parent drug and metabolites are mainly excreted in the urine and its half-life is about 1.5 hours.
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| UMLS_CUI |
C0903898
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| code |
C61858
|
| Chemical_Formula |
C19H27NO3
|
| subClassOf | |
| type | |
| CAS_Registry |
105816-04-4
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| FULL_SYN |
NATEGLINIDE
Nateglinide
Starlix
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| FDA_UNII_Code |
41X3PWK4O2
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| PDQ_Open_Trial_Search_ID |
775333
|
| Contributing_Source |
FDA
|
| Concept_In_Subset |
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