loading...| Preferred Name |
Hydrocortisone Acetate |
|
| Synonyms |
HYDROCORTISONE ACETATE Hydrocortisone Acetate |
|
| Definitions |
The synthetic acetate ester form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties. Hydrocortisone acetate initially binds to the cytoplasmic glucocorticoid receptor; then the receptor-ligand complex is translocated to the nucleus where it initiates the transcription of genes encoding for anti-inflammatory mediators, such as cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61785 |
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| CAS_Registry |
50-03-3 |
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| CHEBI_ID |
CHEBI:17609 |
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| Chemical_Formula |
C23H32O6 |
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| code |
C61785 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
The synthetic acetate ester form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties. Hydrocortisone acetate initially binds to the cytoplasmic glucocorticoid receptor; then the receptor-ligand complex is translocated to the nucleus where it initiates the transcription of genes encoding for anti-inflammatory mediators, such as cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes. |
|
| FDA_UNII_Code |
3X7931PO74 |
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| FULL_SYN |
HYDROCORTISONE ACETATE Hydrocortisone Acetate |
|
| label |
Hydrocortisone Acetate |
|
| Legacy Concept Name |
Hydrocortisone_Acetate |
|
| Preferred_Name |
Hydrocortisone Acetate |
|
| prefixIRI |
Thesaurus:C61785 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0063077 |
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| subClassOf |