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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61776
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61776
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|---|---|
| Preferred Name | Gentian Violet |
| Definitions |
A blue, aniline-derived dye with antifungal and antimitotic properties. Gentian violet (GV) dissociates into positive (GV+) and negative ions (Cl-) that penetrate both gram-positive and gram-negative bacterial cells. The GV+ ions interact with negatively charged components of the bacterial cell wall including lipopolysaccharide, peptidoglycan and DNA. This agent is also a mutagen and mitotic poison. GV elicits a photodynamic action mediated by a free-radical mechanism. Furthermore, this agent dissipates the action potential on prokaryotic or eukaryotic membranes by inducing permeability, thereby leading to respiratory inhibition and subsequent cell death.
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| Synonyms |
Crystal Violet
Basic Violet 3
Hexamethyl-P-Rosaniline Chloride
Gentian Violet
GENTIAN VIOLET
CI 42555
Genapax
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Gentian Violet
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|---|---|
| Legacy Concept Name |
Gentian_Violet
|
| Preferred_Name |
Gentian Violet
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Indicator, Reagent, or Diagnostic Aid
|
| prefixIRI |
Thesaurus:C61776
|
| DEFINITION |
A blue, aniline-derived dye with antifungal and antimitotic properties. Gentian violet (GV) dissociates into positive (GV+) and negative ions (Cl-) that penetrate both gram-positive and gram-negative bacterial cells. The GV+ ions interact with negatively charged components of the bacterial cell wall including lipopolysaccharide, peptidoglycan and DNA. This agent is also a mutagen and mitotic poison. GV elicits a photodynamic action mediated by a free-radical mechanism. Furthermore, this agent dissipates the action potential on prokaryotic or eukaryotic membranes by inducing permeability, thereby leading to respiratory inhibition and subsequent cell death.
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| UMLS_CUI |
C0017440
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| code |
C61776
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| Chemical_Formula |
C25H30N3.Cl
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| subClassOf | |
| NSC Number |
3090
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| type | |
| CAS_Registry |
548-62-9
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| FULL_SYN |
Crystal Violet
Basic Violet 3
Hexamethyl-P-Rosaniline Chloride
Gentian Violet
GENTIAN VIOLET
CI 42555
Genapax
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| FDA_UNII_Code |
J4Z741D6O5
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| Contributing_Source |
FDA
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| Concept_In_Subset |
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