National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Ganirelix Acetate

Synonyms

Ganirelix Acetate

GANIRELIX ACETATE

Definitions

The acetate salt form of ganirelix, a synthetic decapeptide with high antagonistic activity against naturally occurring gonadotropin-releasing hormone (GnRH). Ganirelix directly competes with the GnRH for receptor binding in the anterior pituitary gland, thus induces a rapid and reversible suppression of the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH). This agent is used for the inhibition of premature LH surges in women undergoing controlled ovarian hyperstimulation, and in combination with other hormones for retrieval of the mature follicles for in-vitro fertilization.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61774

CAS_Registry

129311-55-3

Chemical_Formula

C80H113ClN18O13.2C2H4O2

code

C61774

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The acetate salt form of ganirelix, a synthetic decapeptide with high antagonistic activity against naturally occurring gonadotropin-releasing hormone (GnRH). Ganirelix directly competes with the GnRH for receptor binding in the anterior pituitary gland, thus induces a rapid and reversible suppression of the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH). This agent is used for the inhibition of premature LH surges in women undergoing controlled ovarian hyperstimulation, and in combination with other hormones for retrieval of the mature follicles for in-vitro fertilization.

FDA_UNII_Code

56U7906FQW

FULL_SYN

Ganirelix Acetate

GANIRELIX ACETATE

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77423

label

Ganirelix Acetate

Legacy Concept Name

Ganirelix_Acetate

Preferred_Name

Ganirelix Acetate

prefixIRI

Thesaurus:C61774

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0872894

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2092

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