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National Cancer Institute Thesaurus
Last uploaded:
June 2, 2026
| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61746
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61746
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|---|---|
| Preferred Name | Entacapone |
| Definitions |
A nitrocatechol compound with anti-parkinsonian property. Entacapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), which catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a catechol structure including dihydroxyphenylalanine (DOPA), catecholamines (dopamine, norepinephrine, and epinephrine) and their hydroxylated metabolites. When administered in conjunction with dopaminergic agents such as L-DOPA, entacapone prevents the metabolism and inactivation of adjunct drugs, thereby increasing the bioavailability of these compounds by facilitating their passage across the blood-brain barrier.
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| Synonyms |
Comtan
ENTACAPONE
Entacapone
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label | Entacapone
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|---|---|
| prefixIRI | Thesaurus:C61746
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| code | C61746
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| DEFINITION | A nitrocatechol compound with anti-parkinsonian property. Entacapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), which catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a catechol structure including dihydroxyphenylalanine (DOPA), catecholamines (dopamine, norepinephrine, and epinephrine) and their hydroxylated metabolites. When administered in conjunction with dopaminergic agents such as L-DOPA, entacapone prevents the metabolism and inactivation of adjunct drugs, thereby increasing the bioavailability of these compounds by facilitating their passage across the blood-brain barrier.
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| CHEBI_ID | CHEBI:4798
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| Legacy Concept Name | Entacapone
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| PDQ_Open_Trial_Search_ID | 801668
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| Contributing_Source | FDA
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| NCI_Drug_Dictionary_ID | 801668
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| FULL_SYN |
Comtan
ENTACAPONE
Entacapone
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| Chemical_Formula | C14H15N3O5
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| UMLS_CUI | C0876730
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| FDA_UNII_Code | 4975G9NM6T
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| Preferred_Name | Entacapone
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| type | |
| subClassOf | |
| PDQ_Closed_Trial_Search_ID | 801668
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| CAS_Registry | 130929-57-6
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| Concept_In_Subset | |
| Semantic_Type | Pharmacologic Substance
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