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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61706
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61706
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| Preferred Name | Dexbrompheniramine Maleate |
| Definitions |
The maleate salt form of dexbrompheniramine, an alkylamine derivative with anticholinergic and sedative properties. Dexbrompheniramine is a histamine H1-receptor antagonist that competes with histamine for the H1-receptor sites on effector cells in the gastrointestinal tract, blood vessels and respiratory tract. The antagonistic action of this agent blocks the activities of endogenous histamine, which subsequently leads to temporary relief from the negative histamine-mediated symptoms of allergic reaction such as bronchoconstriction, vasodilation, increased capillary permeability and spasmodic contractions of gastrointestinal smooth muscle.
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| Synonyms |
d-Brompheniramine Maleate
(+)-2-(p-Bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine maleate (1:1)
Dexbrompheniramine Maleate
Disomer Maleate
DEXBROMPHENIRAMINE MALEATE
Alahist IR
Alahist PE
Disomer
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label | Dexbrompheniramine Maleate
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| Legacy Concept Name | Dexbrompheniramine_Maleate
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| CHEBI_ID | CHEBI:59273
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| Preferred_Name | Dexbrompheniramine Maleate
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| Semantic_Type | Pharmacologic Substance
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| prefixIRI | Thesaurus:C61706
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| DEFINITION | The maleate salt form of dexbrompheniramine, an alkylamine derivative with anticholinergic and sedative properties. Dexbrompheniramine is a histamine H1-receptor antagonist that competes with histamine for the H1-receptor sites on effector cells in the gastrointestinal tract, blood vessels and respiratory tract. The antagonistic action of this agent blocks the activities of endogenous histamine, which subsequently leads to temporary relief from the negative histamine-mediated symptoms of allergic reaction such as bronchoconstriction, vasodilation, increased capillary permeability and spasmodic contractions of gastrointestinal smooth muscle.
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| UMLS_CUI | C0113291
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| code | C61706
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| Chemical_Formula | C16H19BrN2.C4H4O4
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| subClassOf | |
| type | |
| CAS_Registry | 2391-03-9
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| FULL_SYN |
d-Brompheniramine Maleate
(+)-2-(p-Bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine maleate (1:1)
Dexbrompheniramine Maleate
Disomer Maleate
DEXBROMPHENIRAMINE MALEATE
Alahist IR
Alahist PE
Disomer
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| FDA_UNII_Code | BPA9UT29BS
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| Contributing_Source | FDA
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| Concept_In_Subset | |
| Has_Free_Acid_Or_Base_Form |
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