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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Desipramine | |
| Synonyms |
Desipramine DESIPRAMINE |
|
| Definitions |
An active metabolite of imipramine, a tertiary amine and a synthetic tricyclic derivative of the antidepressant. Desipramine enhances monoamine neurotransmission in certain areas of the brain by inhibiting the re-uptake of noradrenaline and serotonin at the noradrenergic and serotoninergic nerve endings, respectively. It also induces sedation through histamine 1 receptor blockage and hypotension through beta-adrenergic blockage. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61700 |
|
| CAS_Registry |
50-47-5
|
|
| CHEBI_ID |
CHEBI:47781
|
|
| Chemical_Formula |
C18H22N2
|
|
| code |
C61700
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
An active metabolite of imipramine, a tertiary amine and a synthetic tricyclic derivative of the antidepressant. Desipramine enhances monoamine neurotransmission in certain areas of the brain by inhibiting the re-uptake of noradrenaline and serotonin at the noradrenergic and serotoninergic nerve endings, respectively. It also induces sedation through histamine 1 receptor blockage and hypotension through beta-adrenergic blockage.
|
|
| FDA_UNII_Code |
TG537D343B
|
|
| FULL_SYN |
Desipramine DESIPRAMINE
|
|
| Has_Salt_Form | ||
| label |
Desipramine
|
|
| Legacy Concept Name |
Desipramine
|
|
| Preferred_Name |
Desipramine
|
|
| prefixIRI |
Thesaurus:C61700
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0011685
|
|
| subClassOf |
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