Preferred Name |
Cyclophosphamide Anhydrous |
|
Synonyms |
Cyclophosphamide Anhydrous N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-Oxide 2H-1,3,2-oxazaphosphorin-2-amine, N,N-is(2-chloroethyl)tetrahydro-,2-oxide CYCLOPHOSPHAMIDE ANHYDROUS |
|
Definitions |
The anhydrous form of cyclophosphamide, a synthetic nitrogen mustard alkylating agent, with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to active metabolites including phosphoramide mustard, which binds to and crosslinks DNA and RNA, thereby inhibiting DNA replication and protein synthesis. This agent, at low doses, is also a potent immunosuppressant primarily by depleting T-regulatory cells. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61694 |
|
CAS_Registry |
50-18-0 |
|
CHEBI_ID |
CHEBI:4027 |
|
Chemical_Formula |
C7H15Cl2N2O2P |
|
code |
C61694 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
Contributing_Source |
FDA GDC |
|
DEFINITION |
The anhydrous form of cyclophosphamide, a synthetic nitrogen mustard alkylating agent, with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to active metabolites including phosphoramide mustard, which binds to and crosslinks DNA and RNA, thereby inhibiting DNA replication and protein synthesis. This agent, at low doses, is also a potent immunosuppressant primarily by depleting T-regulatory cells. |
|
FDA_UNII_Code |
6UXW23996M |
|
FULL_SYN |
Cyclophosphamide Anhydrous N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-Oxide 2H-1,3,2-oxazaphosphorin-2-amine, N,N-is(2-chloroethyl)tetrahydro-,2-oxide CYCLOPHOSPHAMIDE ANHYDROUS |
|
Is_Value_For_GDC_Property | ||
label |
Cyclophosphamide Anhydrous |
|
Legacy Concept Name |
Cyclophosphamide_Anhydrous |
|
Maps_To |
Cyclophosphamide Anhydrous |
|
Preferred_Name |
Cyclophosphamide Anhydrous |
|
prefixIRI |
Thesaurus:C61694 |
|
Semantic_Type |
Pharmacologic Substance |
|
UMLS_CUI |
C1880207 |
|
subClassOf |
Delete | Mapping To | Ontology | Source |
---|---|---|---|
http://purl.bioontology.org/ontology/RXNORM/1545988 | RXNORM | LOOM | |
http://purl.bioontology.org/ontology/SNOMEDCT/1268997008 | SNOMEDCT | LOOM | |
http://purl.obolibrary.org/obo/NCIT_C61694 | BERO | LOOM |