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National Cancer Institute Thesaurus
| Preferred Name | Recombinant Thyrotropin Alfa | |
| Synonyms |
THYROTROPIN ALFA Recombinant TSH Alpha Recombinant Thyrotropin Alfa Thyroid Stimulating Hormone Alpha thyrotropin alfa Thyrotropin Alfa Recombinant Thyrotropin Alpha TSH-alpha Thyrogen |
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| Definitions |
A recombinant form of the human anterior pituitary glycoprotein thyroid stimulating hormone (TSH) with use in the diagnostic setting. With an amino acid sequence identical to that of human TSH, thyrotropin alfa binds to TSH receptors on normal thyroid epithelial cells or well-differentiated thyroid cancer cells, stimulating iodine uptake and organification, synthesis and secretion of thyroglobulin (Tg), triiodothyronine (T3), and thyroxine (T4). |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61322 |
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| ALT_DEFINITION |
A form of thyroid-stimulating hormone (TSH) that is made in the laboratory. It is used to test for remaining or recurring cancer cells in patients who have been treated for thyroid cancer.
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| CAS_Registry |
194100-83-9
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| code |
C61322
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA GDC
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|
| DEFINITION |
A recombinant form of the human anterior pituitary glycoprotein thyroid stimulating hormone (TSH) with use in the diagnostic setting. With an amino acid sequence identical to that of human TSH, thyrotropin alfa binds to TSH receptors on normal thyroid epithelial cells or well-differentiated thyroid cancer cells, stimulating iodine uptake and organification, synthesis and secretion of thyroglobulin (Tg), triiodothyronine (T3), and thyroxine (T4).
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|
| Display_Name |
Recombinant Thyrotropin Alfa
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| FDA_UNII_Code |
AVX3D5A4LM
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| FULL_SYN |
THYROTROPIN ALFA Recombinant TSH Alpha Recombinant Thyrotropin Alfa Thyroid Stimulating Hormone Alpha thyrotropin alfa Thyrotropin Alfa Recombinant Thyrotropin Alpha TSH-alpha Thyrogen
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| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Recombinant Thyrotropin Alfa
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| Legacy Concept Name |
Recombinant_Thyrotropin_Alfa
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|
| Maps_To |
Recombinant Thyrotropin Alfa
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| NCI_Drug_Dictionary_ID |
481277
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| PDQ_Closed_Trial_Search_ID |
481277
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| PDQ_Open_Trial_Search_ID |
481277
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| Preferred_Name |
Recombinant Thyrotropin Alfa
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| prefixIRI |
Thesaurus:C61322
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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| UMLS_CUI |
C2587204
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| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
| Mapping To | Ontology | Source |
|---|---|---|
| http://purl.obolibrary.org/obo/NCIT_C61322 | BERO | LOOM |
| http://purl.bioontology.org/ontology/PDQ/CDR0000481277 | PDQ | LOOM |