National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Recombinant Interleukin-2

Synonyms

Mitogenic Factor

HUMAN INTERLEUKIN-2

T-Cell Growth Factor

Thymocyte Stimulating Factor

Recombinant interleukin-2

Interleukin II

interleukin-2

Lymphocyte Mitogenic Factor

Recombinant Interleukin-2

Interleukin-2

IL-2

Ro-236019

TCGF

TSF

Definitions

Any recombinant analog of endogenous interleukin-2 (IL-2), a cytokine involved in intercellular communication related to cell differentiation, proliferation, inflammation, hematopoiesis, neuronal functions, and release of hormones. IL-2 binds to and activates specific receptors, triggering expression of specific genes, and may induce T cell-mediated tumor regression in some tumor types.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C587

Accepted_Therapeutic_Use_For

Colorectal cancer; metastatic melanoma; metastatic renal cell carcinoma; Non-Hodgkins lymphoma

ALT_DEFINITION

One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-2 is made by a type of T lymphocyte. It increases the growth and activity of other T lymphocytes and B lymphocytes, and affects the development of the immune system. Aldesleukin (interleukin-2 made in the laboratory) is being used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-2 is a type of cytokine.

code

C587

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

FDA

GDC

DEFINITION

Any recombinant analog of endogenous interleukin-2 (IL-2), a cytokine involved in intercellular communication related to cell differentiation, proliferation, inflammation, hematopoiesis, neuronal functions, and release of hormones. IL-2 binds to and activates specific receptors, triggering expression of specific genes, and may induce T cell-mediated tumor regression in some tumor types.

FDA_UNII_Code

FNO32LO217

FULL_SYN

Mitogenic Factor

HUMAN INTERLEUKIN-2

T-Cell Growth Factor

Thymocyte Stimulating Factor

Recombinant interleukin-2

Interleukin II

interleukin-2

Lymphocyte Mitogenic Factor

Recombinant Interleukin-2

Interleukin-2

IL-2

Ro-236019

TCGF

TSF

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104679

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Recombinant Interleukin-2

Legacy Concept Name

Therapeutic_Interleukin-2

Maps_To

Recombinant Interleukin-2

NCI_Drug_Dictionary_ID

812847

NSC Number

373364

Preferred_Name

Recombinant Interleukin-2

prefixIRI

Thesaurus:C587

Semantic_Type

Amino Acid, Peptide, or Protein

Pharmacologic Substance

UMLS_CUI

C0919268

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C593

Delete Subject Author Type Created
No notes to display