Preferred Name |
Recombinant Interleukin-2 |
|
Synonyms |
Mitogenic Factor HUMAN INTERLEUKIN-2 T-Cell Growth Factor Thymocyte Stimulating Factor Recombinant interleukin-2 Interleukin II interleukin-2 Lymphocyte Mitogenic Factor Recombinant Interleukin-2 Interleukin-2 IL-2 Ro-236019 TCGF TSF |
|
Definitions |
Any recombinant analog of endogenous interleukin-2 (IL-2), a cytokine involved in intercellular communication related to cell differentiation, proliferation, inflammation, hematopoiesis, neuronal functions, and release of hormones. IL-2 binds to and activates specific receptors, triggering expression of specific genes, and may induce T cell-mediated tumor regression in some tumor types. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C587 |
|
Accepted_Therapeutic_Use_For |
Colorectal cancer; metastatic melanoma; metastatic renal cell carcinoma; Non-Hodgkins lymphoma |
|
ALT_DEFINITION |
One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-2 is made by a type of T lymphocyte. It increases the growth and activity of other T lymphocytes and B lymphocytes, and affects the development of the immune system. Aldesleukin (interleukin-2 made in the laboratory) is being used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-2 is a type of cytokine. |
|
code |
C587 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 |
|
Contributing_Source |
FDA GDC |
|
DEFINITION |
Any recombinant analog of endogenous interleukin-2 (IL-2), a cytokine involved in intercellular communication related to cell differentiation, proliferation, inflammation, hematopoiesis, neuronal functions, and release of hormones. IL-2 binds to and activates specific receptors, triggering expression of specific genes, and may induce T cell-mediated tumor regression in some tumor types. |
|
FDA_UNII_Code |
FNO32LO217 |
|
FULL_SYN |
Mitogenic Factor HUMAN INTERLEUKIN-2 T-Cell Growth Factor Thymocyte Stimulating Factor Recombinant interleukin-2 Interleukin II interleukin-2 Lymphocyte Mitogenic Factor Recombinant Interleukin-2 Interleukin-2 IL-2 Ro-236019 TCGF TSF |
|
Has_Target | ||
Is_Value_For_GDC_Property | ||
label |
Recombinant Interleukin-2 |
|
Legacy Concept Name |
Therapeutic_Interleukin-2 |
|
Maps_To |
Recombinant Interleukin-2 |
|
NCI_Drug_Dictionary_ID |
812847 |
|
NSC Number |
373364 |
|
Preferred_Name |
Recombinant Interleukin-2 |
|
prefixIRI |
Thesaurus:C587 |
|
Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
UMLS_CUI |
C0919268 |
|
subClassOf |
Delete | Mapping To | Ontology | Source |
---|---|---|---|
http://purl.obolibrary.org/obo/NCIT_C587 | BERO | LOOM | |
http://purl.bioontology.org/ontology/SNOMEDCT/897192009 | SNOMEDCT | LOOM |