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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C560
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C560
|
|---|---|
| Preferred Name | Hydroxyurea |
| Definitions |
A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04)
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| Synonyms |
Hydroxycarbamide
Hydroxyurea
HYDROXYUREA
Onco-Carbide
Onco-carbide
Oncocarbide
hydroxyurea
Droxia
Hydrea
Litalir
Oxeron
SQ 1089
SQ-1089
Syrea
WR 83799
See more
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Hydroxyurea
|
|---|---|
| Maps_To |
Hydroxyurea
|
| Accepted_Therapeutic_Use_For |
Chronic Myelogenous Leukemia; Head and Neck Cancer; Malignant Melanoma; Ovarian Carcinoma; Sickle Cell Anemia; Adjuvant in Retroviral Therapy.
|
| Legacy Concept Name |
Hydroxyurea
|
| CHEBI_ID |
CHEBI:44423
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| NCI_Drug_Dictionary_ID |
40685
|
| Is_Value_For_GDC_Property | |
| PDQ_Closed_Trial_Search_ID |
40685
|
| Preferred_Name |
Hydroxyurea
|
| Display_Name |
Hydroxyurea
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| prefixIRI |
Thesaurus:C560
|
| DEFINITION |
A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04)
|
| UMLS_CUI |
C0020402
|
| code |
C560
|
| Chemical_Formula |
CH4N2O2
|
| subClassOf | |
| NSC Number |
32065
|
| type | |
| CAS_Registry |
127-07-1
|
| FULL_SYN |
Hydroxycarbamide
Hydroxyurea
HYDROXYUREA
Onco-Carbide
Onco-carbide
Oncocarbide
hydroxyurea
Droxia
Hydrea
Litalir
Oxeron
SQ 1089
SQ-1089
Syrea
WR 83799
See more
See less
|
| FDA_UNII_Code |
X6Q56QN5QC
|
| ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called antimetabolites.
|
| PDQ_Open_Trial_Search_ID |
40685
|
| Contributing_Source |
CTRP
FDA
GDC
HemOnc
|
| Concept_In_Subset |
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|
| Has_Target |
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