National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Phase II Enzymes Inducer
Synonyms

Phase II Enzymes Inducer
Definitions

Any natural or synthetic substance that enhances the activity of any phase II metabolic enzymes. Phase II detoxification enzymes, such as glutathione-S-transferase (GST), glucuronyl transferase, acyl transferase, or sulfotransferase, catalyze conjugation reactions of xenobiotics or metabolites formed in phase I reactions. Conjugation reactions greatly enhance polarity of xenobiotics or their metabolites, thereby facilitate their elimination from the body. Phase II conjugation reactions include glucuronidation, methylation, acetylation, and glutathione, sulfate and amino acid conjugation.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C54630
code

C54630
DEFINITION

Any natural or synthetic substance that enhances the activity of any phase II metabolic enzymes. Phase II detoxification enzymes, such as glutathione-S-transferase (GST), glucuronyl transferase, acyl transferase, or sulfotransferase, catalyze conjugation reactions of xenobiotics or metabolites formed in phase I reactions. Conjugation reactions greatly enhance polarity of xenobiotics or their metabolites, thereby facilitate their elimination from the body. Phase II conjugation reactions include glucuronidation, methylation, acetylation, and glutathione, sulfate and amino acid conjugation.
FULL_SYN

Phase II Enzymes Inducer
label

Phase II Enzymes Inducer
Legacy Concept Name

Phase_II_Enzymes_Inducer
Preferred_Name

Phase II Enzymes Inducer
prefixIRI

Thesaurus:C54630
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C1883668
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1892
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