loading...| Preferred Name |
Octreotide Acetate |
|
| Synonyms |
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hyroxymethyl)propyl]-L-cysteinamide, Cyclic (2->7)-disulfide, Acetate (Salt) OCTREOTIDE ACETATE Longastatina Octreotide Acetate Sandostatina D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide Acetate Longastatin Sandostatin Lar Depot Octreotide acetate SMS 201-995 Sandostatin Sandostatine SMS 201-995 AC Sandostatin LAR Samilstin |
|
| Definitions |
The acetate salt of a synthetic long-acting cyclic octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. Octreotide is a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Similar to somatostatin, this agent also suppresses the luteinizing hormone response to gonadotropin-releasing hormone, decreases splanchnic blood flow, and inhibits the release of serotonin, gastrin, vasoactive intestinal peptide (VIP), secretin, motilin, pancreatic polypeptide, and thyroid stimulating hormone. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C53447 |
|
| Accepted_Therapeutic_Use_For |
Acromegaly; Diarrhea |
|
| CAS_Registry |
79517-01-4 |
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| Chemical_Formula |
C49H66N10O10S2.C2H4O2 |
|
| code |
C53447 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
|
| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
The acetate salt of a synthetic long-acting cyclic octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. Octreotide is a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Similar to somatostatin, this agent also suppresses the luteinizing hormone response to gonadotropin-releasing hormone, decreases splanchnic blood flow, and inhibits the release of serotonin, gastrin, vasoactive intestinal peptide (VIP), secretin, motilin, pancreatic polypeptide, and thyroid stimulating hormone. |
|
| Display_Name |
Octreotide Acetate |
|
| FDA_UNII_Code |
75R0U2568I |
|
| FULL_SYN |
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hyroxymethyl)propyl]-L-cysteinamide, Cyclic (2->7)-disulfide, Acetate (Salt) OCTREOTIDE ACETATE Longastatina Octreotide Acetate Sandostatina D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide Acetate Longastatin Sandostatin Lar Depot Octreotide acetate SMS 201-995 Sandostatin Sandostatine SMS 201-995 AC Sandostatin LAR Samilstin |
|
| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Octreotide Acetate |
|
| Legacy Concept Name |
Octreotide_Acetate |
|
| Maps_To |
Octreotide Acetate |
|
| NCI_Drug_Dictionary_ID |
38866 |
|
| NSC Number |
671663 |
|
| PDQ_Closed_Trial_Search_ID |
38866 |
|
| PDQ_Open_Trial_Search_ID |
38866 |
|
| Preferred_Name |
Octreotide Acetate |
|
| prefixIRI |
Thesaurus:C53447 |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| UMLS_CUI |
C0678117 |
|
| subClassOf |