loading...| Preferred Name |
Ropivacaine Hydrochloride |
|
| Synonyms |
Ropivacaine Hydrochloride ROPIVACAINE HYDROCHLORIDE ropivacaine hydrochloride S-(-)-1-propyl-2,6-pipecoloxylidide Hydrochloride Monohydrate Ropivacaine Hydrochloride Monohydrate (S)-(-)-1-Propylpiperidine-2-carboxylic acid (2,6-dimethylphenyl)amide Hydrochloride Monohydrate Naropin |
|
| Definitions |
The hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity. Ropivacaine binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions and resulting in a stabilization of the neuronal membrane and inhibition of depolarization; nerve impulse generation and propagation are blocked, resulting in a reversible loss of sensation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52198 |
|
| ALT_DEFINITION |
A drug used to control pain and to cause a temporary loss of feeling in one part of the body, during and after surgery. It is also being studied for pain control after cancer surgery. It is a type of local anesthetic. |
|
| CAS_Registry |
132112-35-7 |
|
| CHEBI_ID |
CHEBI:34954 |
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| Chemical_Formula |
C17H26N2O.HCl.H2O |
|
| code |
C52198 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA |
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| DEFINITION |
The hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity. Ropivacaine binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions and resulting in a stabilization of the neuronal membrane and inhibition of depolarization; nerve impulse generation and propagation are blocked, resulting in a reversible loss of sensation. |
|
| Display_Name |
Ropivacaine Hydrochloride |
|
| FDA_UNII_Code |
V910P86109 |
|
| FULL_SYN |
Ropivacaine Hydrochloride ROPIVACAINE HYDROCHLORIDE ropivacaine hydrochloride S-(-)-1-propyl-2,6-pipecoloxylidide Hydrochloride Monohydrate Ropivacaine Hydrochloride Monohydrate (S)-(-)-1-Propylpiperidine-2-carboxylic acid (2,6-dimethylphenyl)amide Hydrochloride Monohydrate Naropin |
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Ropivacaine Hydrochloride |
|
| Legacy Concept Name |
Ropivicaine_Hydrochloride |
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| NCI_Drug_Dictionary_ID |
459953 |
|
| PDQ_Closed_Trial_Search_ID |
459953 |
|
| PDQ_Open_Trial_Search_ID |
459953 |
|
| Preferred_Name |
Ropivacaine Hydrochloride |
|
| prefixIRI |
Thesaurus:C52198 |
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| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0771826 |
|
| subClassOf |