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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C509
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C509
|
|---|---|
| Preferred Name | Flutamide |
| Definitions |
A toluidine derivative and a nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. (NCI04)
|
| Synonyms |
Alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidide
2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
Prostogenat
Propanamide, 2-Methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-
Prostadirex
4'-Nitro-3'-trifluoromethylisobutyranilide
Apimid
Cebatrol
Chimax
Cytomid
Drogenil
Euflex
Eulexin
Eulexine
FLUT
FLUTAMIDE
Flucinom
Flucinome
Flugerel
Fluken
Flulem
Fluta-Gry
Flutabene
Flutacan
Flutamex
Flutamide
Flutamin
Flutan
Flutaplex
Fugerel
Grisetin
Niftolide
Oncosal
Profamid
Prostacur
Prostica
SCH 13521
Sch 13521
Tafenil
Tecnoflut
Testotard
flutamide
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|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Flutamide
|
|---|---|
| Maps_To |
Flutamide
|
| Accepted_Therapeutic_Use_For |
Hirsutism; Prostate carcinoma
|
| Legacy Concept Name |
Flutamide
|
| CHEBI_ID |
CHEBI:5132
|
| NCI_Drug_Dictionary_ID |
39811
|
| Is_Value_For_GDC_Property | |
| PDQ_Closed_Trial_Search_ID |
39811
|
| Preferred_Name |
Flutamide
|
| Display_Name |
Flutamide
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| prefixIRI |
Thesaurus:C509
|
| DEFINITION |
A toluidine derivative and a nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. (NCI04)
|
| UMLS_CUI |
C0016384
|
| code |
C509
|
| Chemical_Formula |
C11H11F3N2O3
|
| subClassOf | |
| NSC Number |
147834
215876
|
| type | |
| CAS_Registry |
13311-84-7
|
| FULL_SYN |
Alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidide
2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
Prostogenat
Propanamide, 2-Methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-
Prostadirex
4'-Nitro-3'-trifluoromethylisobutyranilide
Apimid
Cebatrol
Chimax
Cytomid
Drogenil
Euflex
Eulexin
Eulexine
FLUT
FLUTAMIDE
Flucinom
Flucinome
Flugerel
Fluken
Flulem
Fluta-Gry
Flutabene
Flutacan
Flutamex
Flutamide
Flutamin
Flutan
Flutaplex
Fugerel
Grisetin
Niftolide
Oncosal
Profamid
Prostacur
Prostica
SCH 13521
Sch 13521
Tafenil
Tecnoflut
Testotard
flutamide
See more
See less
|
| FDA_UNII_Code |
76W6J0943E
|
| ALT_DEFINITION |
An anticancer drug that is a type of antiandrogen.
|
| PDQ_Open_Trial_Search_ID |
39811
|
| Contributing_Source |
CTRP
FDA
GDC
HemOnc
OORO
|
| Concept_In_Subset |
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|
| Has_Target |
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