National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Id http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C506
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C506
Preferred Name

Fluoxetine
Definitions
A diphenhydramine derivative and selective serotonin reuptake inhibitor with antidepressant, anti-anxiety, antiobsessional and antibulimic activity and with potential immunomodulating activity. Upon administration, fluoxetine binds to the presynaptic serotonin (5-HT) receptor resulting in negative allosteric modulation of the receptor complex, thereby blocking recycling of serotonin by the presynaptic receptor. Inhibition of serotonin reuptake by fluoxetine enhances serotonergic function through serotonin accumulation in the synaptic space, resulting in long-term desensitization and downregulation of 5-HT receptors, preventing 5-HT-mediated signaling and leading to antidepressant, anti-anxiety, antiobsessional and antibulimic effects. In addition, fluoxetine may inhibit the expression of pro-inflammatory cytokines, including interleukin-6 (IL-6). This may prevent IL-6-mediated inflammation and cytokine storm.
Synonyms
N-methyl-gamma-(4-(trifluoromethyl) -phenoxy)-benzenepropanamine
FLUOXETINE
Fluoxetine
fluoxetine
Type http://www.w3.org/2002/07/owl#Class

All Properties

label
Fluoxetine
Accepted_Therapeutic_Use_For
Depression
Legacy Concept Name
Fluoxetine
CHEBI_ID
CHEBI:5118
NCI_Drug_Dictionary_ID
41578
PDQ_Closed_Trial_Search_ID
41578
Preferred_Name
Fluoxetine
Display_Name
Fluoxetine
Semantic_Type
Organic Chemical
Pharmacologic Substance
prefixIRI
Thesaurus:C506
DEFINITION
A diphenhydramine derivative and selective serotonin reuptake inhibitor with antidepressant, anti-anxiety, antiobsessional and antibulimic activity and with potential immunomodulating activity. Upon administration, fluoxetine binds to the presynaptic serotonin (5-HT) receptor resulting in negative allosteric modulation of the receptor complex, thereby blocking recycling of serotonin by the presynaptic receptor. Inhibition of serotonin reuptake by fluoxetine enhances serotonergic function through serotonin accumulation in the synaptic space, resulting in long-term desensitization and downregulation of 5-HT receptors, preventing 5-HT-mediated signaling and leading to antidepressant, anti-anxiety, antiobsessional and antibulimic effects. In addition, fluoxetine may inhibit the expression of pro-inflammatory cytokines, including interleukin-6 (IL-6). This may prevent IL-6-mediated inflammation and cytokine storm.
UMLS_CUI
C0016365
code
C506
Chemical_Formula
C17H18F3NO
subClassOf
type
CAS_Registry
54910-89-3
FULL_SYN
N-methyl-gamma-(4-(trifluoromethyl) -phenoxy)-benzenepropanamine
FLUOXETINE
Fluoxetine
fluoxetine
FDA_UNII_Code
01K63SUP8D
ALT_DEFINITION
A drug used to treat depression. It belongs to the family of drugs called antidepressants.
PDQ_Open_Trial_Search_ID
41578
Contributing_Source
CTRP
FDA
Concept_In_Subset
Has_Salt_Form
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