Preferred Name |
Flucytosine |
|
Synonyms |
Flucytosine 5-Fluorocytosine flucytosine 4-Amino-5-fluoro-2(1H)-pyrimidinone FLUCYTOSINE 5-FC Alcobon Ancobon Ancotil Ro 2-9915 Ro-2-9915 |
|
Definitions |
A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C501 |
|
ALT_DEFINITION |
A drug that treats infections caused by fungi. |
|
CAS_Registry |
2022-85-7 |
|
CHEBI_ID |
CHEBI:5100 |
|
Chemical_Formula |
C4H4FN3O |
|
code |
C501 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
Contributing_Source |
CTRP FDA |
|
DEFINITION |
A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis. |
|
Display_Name |
Flucytosine |
|
FDA_UNII_Code |
D83282DT06 |
|
FULL_SYN |
Flucytosine 5-Fluorocytosine flucytosine 4-Amino-5-fluoro-2(1H)-pyrimidinone FLUCYTOSINE 5-FC Alcobon Ancobon Ancotil Ro 2-9915 Ro-2-9915 |
|
label |
Flucytosine |
|
Legacy Concept Name |
Flucytosine |
|
NCI_Drug_Dictionary_ID |
41023 |
|
NSC Number |
103805 |
|
PDQ_Closed_Trial_Search_ID |
41023 |
|
PDQ_Open_Trial_Search_ID |
41023 |
|
Preferred_Name |
Flucytosine |
|
prefixIRI |
Thesaurus:C501 |
|
Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
|
UMLS_CUI |
C0016278 |
|
subClassOf |