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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C501
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C501
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|---|---|
| Preferred Name | Flucytosine |
| Definitions |
A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis.
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| Synonyms |
Flucytosine
5-Fluorocytosine
flucytosine
4-Amino-5-fluoro-2(1H)-pyrimidinone
FLUCYTOSINE
5-FC
Alcobon
Ancobon
Ancotil
Ro 2-9915
Ro-2-9915
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label | Flucytosine
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|---|---|
| Legacy Concept Name | Flucytosine
|
| CHEBI_ID | CHEBI:5100
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| NCI_Drug_Dictionary_ID | 41023
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| PDQ_Closed_Trial_Search_ID | 41023
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| Preferred_Name | Flucytosine
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| Display_Name | Flucytosine
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| prefixIRI | Thesaurus:C501
|
| DEFINITION | A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis.
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| UMLS_CUI | C0016278
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| code | C501
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| Chemical_Formula | C4H4FN3O
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| subClassOf | |
| NSC Number | 103805
|
| type | |
| CAS_Registry | 2022-85-7
|
| FULL_SYN |
Flucytosine
5-Fluorocytosine
flucytosine
4-Amino-5-fluoro-2(1H)-pyrimidinone
FLUCYTOSINE
5-FC
Alcobon
Ancobon
Ancotil
Ro 2-9915
Ro-2-9915
See more
See less
|
| FDA_UNII_Code | D83282DT06
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| ALT_DEFINITION | A drug that treats infections caused by fungi.
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| PDQ_Open_Trial_Search_ID | 41023
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| Contributing_Source |
CTRP
FDA
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| Concept_In_Subset |
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