National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Id http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49185
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49185
Preferred Name

Thiazide Diuretic
Definitions
Any benzothiadiazide derivative or other thiazide-like agent with diuretic and anti-hypertensive activity. Thiazide diuretics inhibit the sodium-chloride transporter in the distal tubule in the kidneys, thereby suppressing sodium and chloride reabsorption from the distal convoluted tubules (DCT) and increasing the excretion of sodium, chloride, potassium and water. In addition, thiazide diuretics decrease excretion of calcium and uric acid. These agents cause vasodilation possibly by activating calcium-activated potassium channels in vascular smooth muscle and inhibiting various carbonic anhydrases in vascular tissue.
Synonyms
Thiazide Diuretic
Type http://www.w3.org/2002/07/owl#Class

All Properties

label
Thiazide Diuretic
Legacy Concept Name
Thiazide_Diuretic
Preferred_Name
Thiazide Diuretic
Semantic_Type
Chemical Viewed Functionally
prefixIRI
Thesaurus:C49185
DEFINITION
Any benzothiadiazide derivative or other thiazide-like agent with diuretic and anti-hypertensive activity. Thiazide diuretics inhibit the sodium-chloride transporter in the distal tubule in the kidneys, thereby suppressing sodium and chloride reabsorption from the distal convoluted tubules (DCT) and increasing the excretion of sodium, chloride, potassium and water. In addition, thiazide diuretics decrease excretion of calcium and uric acid. These agents cause vasodilation possibly by activating calcium-activated potassium channels in vascular smooth muscle and inhibiting various carbonic anhydrases in vascular tissue.
UMLS_CUI
C3536861
code
C49185
subClassOf
type
FULL_SYN
Thiazide Diuretic
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