loading...| Preferred Name | Estrogens, Conjugated | |
| Synonyms |
ESTROGENS, CONJUGATED Estrogens, Conjugated ATC:G03CA57 Conjugated Estrogens Conestron Femest Premarin Sodestrin Tag-39 |
|
| Definitions |
Purified orally bioavailable female sex hormones isolated from pregnant mare urine or synthetically derived from plant materials and primarily conjugated as sulfate esters. Estrogen binds to and activates specific nuclear receptors, which, in turn, bind to estrogen response elements (EREs) in target genes, resulting in histone acetylation, alteration of chromatin conformation, and initiation of transcription. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C482 |
|
| Accepted_Therapeutic_Use_For |
Advanced androgen-dependent prostate cancer, palliative; Breast cancer, palliative; Estrogen replacement; Menopausal symptoms; Postmenopausal osteoporosis |
|
| CAS_Registry |
12126-59-9 |
|
| code |
C482 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 |
|
| Contributing_Source |
FDA GDC |
|
| DEFINITION |
Purified orally bioavailable female sex hormones isolated from pregnant mare urine or synthetically derived from plant materials and primarily conjugated as sulfate esters. Estrogen binds to and activates specific nuclear receptors, which, in turn, bind to estrogen response elements (EREs) in target genes, resulting in histone acetylation, alteration of chromatin conformation, and initiation of transcription. (NCI04) |
|
| FDA_UNII_Code |
IU5QR144QX |
|
| FULL_SYN |
ESTROGENS, CONJUGATED Estrogens, Conjugated ATC:G03CA57 Conjugated Estrogens Conestron Femest Premarin Sodestrin Tag-39 |
|
| Is_Value_For_GDC_Property | ||
| label |
Estrogens, Conjugated |
|
| Legacy Concept Name |
Conjugated_Estrogens |
|
| Maps_To |
Estrogens, Conjugated |
|
| NCI_Drug_Dictionary_ID |
39237 |
|
| NSC Number |
18313 |
|
| PDQ_Closed_Trial_Search_ID |
39237 |
|
| PDQ_Open_Trial_Search_ID |
39237 |
|
| Preferred_Name |
Estrogens, Conjugated |
|
| prefixIRI |
Thesaurus:C482 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0014938 |
|
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.bioontology.org/ontology/VANDF/4018403 | VANDF | LOOM | |
| http://purl.bioontology.org/ontology/NDDF/001272 | NDDF | LOOM | |
| http://purl.obolibrary.org/obo/NCIT_C482 | BERO | LOOM | |
| http://purl.bioontology.org/ontology/NDFRT/N0000146729 | NDFRT | LOOM |