Link to this page
National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
Jump to:
| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48031
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48031
|
|---|---|
| Preferred Name | Ziprasidone Hydrochloride |
| Definitions |
The hydrochloride salt form of ziprasidone, a benzothiazolylpiperazine derivative and an atypical antipsychotic agent with an antischizophrenic property. Ziprasidone hydrochloride functions as an antagonist at the dopamine D2 and serotonin 5-HT2A and 5-HT1D receptors, and as an agonist at the 5-HT1A receptor. Ziprasidone hydrochloride also inhibits synaptic reuptake of serotonin and norepinephrine. The mechanism of action by which ziprasidone hydrochloride exerts its antischizophrenic effect is unknown but is potentially mediated through a combination of dopamine D2 and serotonin 5-HT2 antagonism. This agent also has antagonistic activity against histamine H1 and alpha-1-adrenergic receptors.
|
| Synonyms |
5-(2-(4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-Indol-2-one Monohydrochloride
Geodon, Capsules
Ziprasidone Hydrochloride
ZIPRASIDONE HYDROCHLORIDE
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Ziprasidone Hydrochloride
|
|---|---|
| Legacy Concept Name |
Ziprasidone_Hydrochloride
|
| CHEBI_ID |
CHEBI:32314
|
| Preferred_Name |
Ziprasidone Hydrochloride
|
| Semantic_Type |
Pharmacologic Substance
|
| prefixIRI |
Thesaurus:C48031
|
| DEFINITION |
The hydrochloride salt form of ziprasidone, a benzothiazolylpiperazine derivative and an atypical antipsychotic agent with an antischizophrenic property. Ziprasidone hydrochloride functions as an antagonist at the dopamine D2 and serotonin 5-HT2A and 5-HT1D receptors, and as an agonist at the 5-HT1A receptor. Ziprasidone hydrochloride also inhibits synaptic reuptake of serotonin and norepinephrine. The mechanism of action by which ziprasidone hydrochloride exerts its antischizophrenic effect is unknown but is potentially mediated through a combination of dopamine D2 and serotonin 5-HT2 antagonism. This agent also has antagonistic activity against histamine H1 and alpha-1-adrenergic receptors.
|
| UMLS_CUI |
C0380392
|
| code |
C48031
|
| Chemical_Formula |
C21H21ClN4OS.ClH.H2O
|
| subClassOf | |
| type | |
| CAS_Registry |
138982-67-9
122883-93-6
|
| FULL_SYN |
5-(2-(4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-Indol-2-one Monohydrochloride
Geodon, Capsules
Ziprasidone Hydrochloride
ZIPRASIDONE HYDROCHLORIDE
|
| FDA_UNII_Code |
216X081ORU
|
| Contributing_Source |
FDA
|
| Concept_In_Subset | |
| Has_Free_Acid_Or_Base_Form |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |