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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Valproate Sodium | |
| Synonyms |
VALPROATE SODIUM 2-Propylpentanoic Acid Sodium Salt Valproate Sodium Depacon Ergenyl |
|
| Definitions |
The sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in blood. Although the mechanism of action remains to be elucidated, valproate sodium increases concentrations of gamma-aminobutyric acid (GABA) in the brain, probably due to inhibition of the enzymes responsible for the catabolism of GABA. This potentiates the synaptic actions of GABA. Valproate sodium may also affect potassium channels, thereby creating a direct membrane-stabilizing effect. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48029 |
|
| CAS_Registry |
1069-66-5
|
|
| CHEBI_ID |
CHEBI:9925
|
|
| Chemical_Formula |
C8H15O2.Na
|
|
| code |
C48029
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
The sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in blood. Although the mechanism of action remains to be elucidated, valproate sodium increases concentrations of gamma-aminobutyric acid (GABA) in the brain, probably due to inhibition of the enzymes responsible for the catabolism of GABA. This potentiates the synaptic actions of GABA. Valproate sodium may also affect potassium channels, thereby creating a direct membrane-stabilizing effect.
|
|
| FDA_UNII_Code |
5VOM6GYJ0D
|
|
| FULL_SYN |
VALPROATE SODIUM 2-Propylpentanoic Acid Sodium Salt Valproate Sodium Depacon Ergenyl
|
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Valproate Sodium
|
|
| Legacy Concept Name |
Valproate_Sodium
|
|
| Preferred_Name |
Valproate Sodium
|
|
| prefixIRI |
Thesaurus:C48029
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0037567
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|
| subClassOf |
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