loading...| Preferred Name |
Phenytoin Sodium |
|
| Synonyms |
Phenytoin Sodium PHENYTOIN SODIUM phenytoin sodium 5,5-Diphenyl-2,4-imidazolidinedione, Monosodium Salt Dilantin |
|
| Definitions |
The sodium salt form of phenytoin, a hydantoin derivate and non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin sodium promotes sodium efflux from neurons located in the motor cortex, thereby stabilizing the neuron and inhibiting synaptic transmission. This leads to a reduction in posttetanic potentiation at synapses, an inhibition of repetitive firing of action potentials and ultimately inhibits the spread of seizure activity. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48011 |
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| ALT_DEFINITION |
A drug used to treat or prevent seizures or convulsions that may be caused by epilepsy, brain surgery, or treatment for brain cancer. It is a type of anticonvulsant agent. |
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| CAS_Registry |
630-93-3 |
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| Chemical_Formula |
C15H11N2O2.Na |
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| code |
C48011 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 |
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| Contributing_Source |
FDA GDC |
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| DEFINITION |
The sodium salt form of phenytoin, a hydantoin derivate and non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin sodium promotes sodium efflux from neurons located in the motor cortex, thereby stabilizing the neuron and inhibiting synaptic transmission. This leads to a reduction in posttetanic potentiation at synapses, an inhibition of repetitive firing of action potentials and ultimately inhibits the spread of seizure activity. |
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| FDA_UNII_Code |
4182431BJH |
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| FULL_SYN |
Phenytoin Sodium PHENYTOIN SODIUM phenytoin sodium 5,5-Diphenyl-2,4-imidazolidinedione, Monosodium Salt Dilantin |
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| Has_Free_Acid_Or_Base_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Phenytoin Sodium |
|
| Legacy Concept Name |
Phenytoin_Sodium |
|
| Maps_To |
Phenytoin Sodium |
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| NSC Number |
8722 |
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| Preferred_Name |
Phenytoin Sodium |
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| prefixIRI |
Thesaurus:C48011 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0237417 |
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| subClassOf |