loading...| Preferred Name |
Estramustine Phosphate Sodium |
|
| Synonyms |
Estramustine phosphate Estramustine 17-(Dihydrogenphosphate) Disodium Salt Ro-21-8837/001 Estramustine Phosphate Estramustine Sodium Phosphate Estramustine Phosphate Sodium ESTRAMUSTINE PHOSPHATE SODIUM Estramustine sodium phosphate Emcyt Estracyt Leo 299 Leo-299 |
|
| Definitions |
The orally available disodium salt, monohydrate, of estramustine phosphate, a synthetic molecule that combines estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C480 |
|
| CAS_Registry |
52205-73-9 |
|
| CHEBI_ID |
CHEBI:31562 |
|
| Chemical_Formula |
C23H30Cl2NO6P.2Na |
|
| code |
C480 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
The orally available disodium salt, monohydrate, of estramustine phosphate, a synthetic molecule that combines estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. |
|
| Display_Name |
Estramustine Phosphate Sodium |
|
| FDA_UNII_Code |
75F375MT2N |
|
| FULL_SYN |
Estramustine phosphate Estramustine 17-(Dihydrogenphosphate) Disodium Salt Ro-21-8837/001 Estramustine Phosphate Estramustine Sodium Phosphate Estramustine Phosphate Sodium ESTRAMUSTINE PHOSPHATE SODIUM Estramustine sodium phosphate Emcyt Estracyt Leo 299 Leo-299 |
|
| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Estramustine Phosphate Sodium |
|
| Legacy Concept Name |
Estramustine_Phosphate_Sodium |
|
| Maps_To |
Estramustine Phosphate Sodium |
|
| NCI_Drug_Dictionary_ID |
39235 |
|
| NSC Number |
89199 |
|
| PDQ_Closed_Trial_Search_ID |
39235 |
|
| PDQ_Open_Trial_Search_ID |
39235 |
|
| Preferred_Name |
Estramustine Phosphate Sodium |
|
| prefixIRI |
Thesaurus:C480 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0014922 |
|
| subClassOf |