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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47763
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47763
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|---|---|
| Preferred Name | Tolnaftate |
| Definitions |
A thiocarbamate derivative with either fungicidal or fungistatic property. Tolnaftate is a selective, reversible and non-competitive inhibitor of membrane-bound squalene-2,3- epoxidase, an enzyme involved in the biosynthesis of ergosterol. Inhibition leads to the accumulation of squalene and a deficiency in ergosterol, an essential component of fungal cell walls, thereby increasing membrane permeability, disrupting cellular organization and causing cell death. In addition, this agent may also distort the hyphae and stunts mycelial growth in susceptible fungi.
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| Synonyms |
Carbanilic Acid, m,N-dimethylthio-, O-2-naphthyl Ester
Carbamothioic Acid, methyl(3-methylphenyl)-, O-2-naphthalenyl Ester
Absorbine
Aftate
Desenex
Focusan
Genaspor
NP 27
TOLNAFTATE
Tinactin
Tolnaftate
Tolsanil
See more
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|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Tolnaftate
|
|---|---|
| Legacy Concept Name |
Tolnaftate
|
| Preferred_Name |
Tolnaftate
|
| Semantic_Type |
Pharmacologic Substance
|
| prefixIRI |
Thesaurus:C47763
|
| DEFINITION |
A thiocarbamate derivative with either fungicidal or fungistatic property. Tolnaftate is a selective, reversible and non-competitive inhibitor of membrane-bound squalene-2,3- epoxidase, an enzyme involved in the biosynthesis of ergosterol. Inhibition leads to the accumulation of squalene and a deficiency in ergosterol, an essential component of fungal cell walls, thereby increasing membrane permeability, disrupting cellular organization and causing cell death. In addition, this agent may also distort the hyphae and stunts mycelial growth in susceptible fungi.
|
| UMLS_CUI |
C0040379
|
| code |
C47763
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| Chemical_Formula |
C19H17NOS
|
| subClassOf | |
| NSC Number |
233648
|
| type | |
| CAS_Registry |
2398-96-1
|
| FULL_SYN |
Carbanilic Acid, m,N-dimethylthio-, O-2-naphthyl Ester
Carbamothioic Acid, methyl(3-methylphenyl)-, O-2-naphthalenyl Ester
Absorbine
Aftate
Desenex
Focusan
Genaspor
NP 27
TOLNAFTATE
Tinactin
Tolnaftate
Tolsanil
See more
See less
|
| FDA_UNII_Code |
06KB629TKV
|
| Contributing_Source |
FDA
|
| Concept_In_Subset |
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