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National Cancer Institute Thesaurus
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February 23, 2024
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Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47743
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47743
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Preferred Name | Tadalafil |
Definitions |
A carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection.
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Synonyms |
(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
Cialis
Ic351
TADALAFIL
Tadalafil
tadalafil
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Type | http://www.w3.org/2002/07/owl#Class |
All Properties
label | Tadalafil
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Accepted_Therapeutic_Use_For | Benign Prostatic Hyperplasia
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Legacy Concept Name | Tadalafil
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NCI_Drug_Dictionary_ID | 462366
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PDQ_Closed_Trial_Search_ID | 462366
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Preferred_Name | Tadalafil
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Display_Name | Tadalafil
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Semantic_Type | Pharmacologic Substance
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prefixIRI | Thesaurus:C47743
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DEFINITION | A carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection.
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UMLS_CUI | C1176316
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code | C47743
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Chemical_Formula | C22H19N3O4
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subClassOf | |
type | |
CAS_Registry | 171596-29-5
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FULL_SYN | (6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
Cialis
Ic351
TADALAFIL
Tadalafil
tadalafil
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FDA_UNII_Code | 742SXX0ICT
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ALT_DEFINITION | A drug used to treat erectile dysfunction. It is also being studied in the treatment of sexual problems in patients treated with radiation or surgery for prostate cancer. Tadalafil blocks the action of a certain enzyme, which can result in increased blood flow to the penis, causing an erection. It is a type of cGMP phosphodiesterase type 5 (PDE5) inhibitor.
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PDQ_Open_Trial_Search_ID | 462366
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Contributing_Source |
CTRP
FDA
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Concept_In_Subset |
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/ontologies/NCIT/notes/https%3A%2F%2Fdata.bioontology.org%2Fnotes%2F8dfd5db0-bd90-0136-3c5b-005056010073 | tabasco_tabata%40yahoo.co.jp | Comment | 2018-10-29 | |
New concept - total skin sparing mastectomy | anonymous | Comment | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C15277 | 2013-05-22 |
RE: Antineoplastic antibiotics are antibiotics (?) | rwynne | Comment | 2013-02-13 | |
Antineoplastic antibiotics are antibiotics (?) | coulet | Comment | 2013-01-25 | |
Test note | decorons | Comment | 2011-02-07 | |
New Term Proposal: abcd | fergerson | New Class Proposal | 2010-12-17 | |
relationship with Smoking Behavior | pkcourtney | Comment | 2010-06-22 | |
causes and symptoms | linairis | Comment | 2009-08-06 | |
NIH-What Causes COPD | linairis | Comment | 2009-08-06 | |
The treatment of COPD | linairis | Comment | 2009-08-06 | |
MedlinePlus | linairis | Comment | 2009-08-06 | |
decorons | Comment | 2008-12-31 | ||
decorons | Comment | 2008-12-31 | ||
decorons | Comment | 2008-12-31 | ||
decorons | Comment | 2008-12-31 | ||
An image example for melanoma | jonquet | Comment | 2008-08-06 | |
Wikipedia page on 'melanoma' | jonquet | Comment | 2008-08-06 |
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