loading...| Preferred Name | Tadalafil | |
| Synonyms |
(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione Cialis Ic351 TADALAFIL Tadalafil tadalafil |
|
| Definitions |
A carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47743 |
|
| Accepted_Therapeutic_Use_For |
Benign Prostatic Hyperplasia |
|
| ALT_DEFINITION |
A drug used to treat erectile dysfunction. It is also being studied in the treatment of sexual problems in patients treated with radiation or surgery for prostate cancer. Tadalafil blocks the action of a certain enzyme, which can result in increased blood flow to the penis, causing an erection. It is a type of cGMP phosphodiesterase type 5 (PDE5) inhibitor. |
|
| CAS_Registry |
171596-29-5 |
|
| Chemical_Formula |
C22H19N3O4 |
|
| code |
C47743 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection. |
|
| Display_Name |
Tadalafil |
|
| FDA_UNII_Code |
742SXX0ICT |
|
| FULL_SYN |
(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione Cialis Ic351 TADALAFIL Tadalafil tadalafil |
|
| label |
Tadalafil |
|
| Legacy Concept Name |
Tadalafil |
|
| NCI_Drug_Dictionary_ID |
462366 |
|
| PDQ_Closed_Trial_Search_ID |
462366 |
|
| PDQ_Open_Trial_Search_ID |
462366 |
|
| Preferred_Name |
Tadalafil |
|
| prefixIRI |
Thesaurus:C47743 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C1176316 |
|
| subClassOf |