loading...| Preferred Name | Pyrithione Zinc | |
| Synonyms |
Zinc, bis(2-pyridylthio)-, N,N'-dioxide 2-Mercaptopyridine 1-oxide Zinc Salt Zinc Pyrithione Zinc Pyridine-2-thiol 1-oxide PYRITHIONE ZINC Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)- Bis(1-hydroxy-2(1H)-pyridinethionato)zinc Pyrithione Zinc |
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| Definitions |
A coordination complex of the zinc ion and pyrithione, a derivative of the naturally occurring antibiotic aspergillic acid with antimicrobial, antifungal and anti-seborrheic effects. Although the exact mechanism of action remains to be fully elucidated, pyrithione zinc appears to interfere with the membrane transport of ions and metabolites, ultimately leading to a loss of metabolic control. In addition, this agent causes an influx of copper, leading to a reduction in the activity of iron-sulphur proteins resulting in growth inhibition. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47698 |
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| CAS_Registry |
13463-41-7 3590-23-6 |
|
| CHEBI_ID |
CHEBI:32076 |
|
| Chemical_Formula |
2C5H4NOS.Zn |
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| code |
C47698 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A coordination complex of the zinc ion and pyrithione, a derivative of the naturally occurring antibiotic aspergillic acid with antimicrobial, antifungal and anti-seborrheic effects. Although the exact mechanism of action remains to be fully elucidated, pyrithione zinc appears to interfere with the membrane transport of ions and metabolites, ultimately leading to a loss of metabolic control. In addition, this agent causes an influx of copper, leading to a reduction in the activity of iron-sulphur proteins resulting in growth inhibition. |
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| FDA_UNII_Code |
R953O2RHZ5 |
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| FULL_SYN |
Zinc, bis(2-pyridylthio)-, N,N'-dioxide 2-Mercaptopyridine 1-oxide Zinc Salt Zinc Pyrithione Zinc Pyridine-2-thiol 1-oxide PYRITHIONE ZINC Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)- Bis(1-hydroxy-2(1H)-pyridinethionato)zinc Pyrithione Zinc |
|
| label |
Pyrithione Zinc |
|
| Legacy Concept Name |
Pyrithione_Zinc |
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| NSC Number |
290409 |
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| Preferred_Name |
Pyrithione Zinc |
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| prefixIRI |
Thesaurus:C47698 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0078792 |
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| subClassOf |