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National Cancer Institute Thesaurus
| Preferred Name | Potassium Perchlorate | |
| Synonyms |
Perchloric Acid, Potassium Salt Potassium Perchlorate POTASSIUM PERCHLORATE Perchloracap Astrumal |
|
| Definitions |
The potassium salt of perchloric acid and a member of the Hofmeister ions series with thyroid blocking properties. Potassium perchlorate is a competitive inhibitor of iodine uptake through inhibiting the sodium-iodide symporter (NIS) on the thyroid follicular cell membrane. This results in a potential decrease in thyroid hormone synthesis including thyroxine (T4) and tri-iodothyronine (T3). In addition, this agent decreases the accumulation of the radioactive imaging substance and Hofmeister series ion, pertechnetate Tc 99m, in the choroid plexus and in the salivary and thyroid glands through competitive displacing. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47681 |
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| CAS_Registry |
7778-74-7
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| Chemical_Formula |
ClO4.K
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|
| code |
C47681
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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|
| DEFINITION |
The potassium salt of perchloric acid and a member of the Hofmeister ions series with thyroid blocking properties. Potassium perchlorate is a competitive inhibitor of iodine uptake through inhibiting the sodium-iodide symporter (NIS) on the thyroid follicular cell membrane. This results in a potential decrease in thyroid hormone synthesis including thyroxine (T4) and tri-iodothyronine (T3). In addition, this agent decreases the accumulation of the radioactive imaging substance and Hofmeister series ion, pertechnetate Tc 99m, in the choroid plexus and in the salivary and thyroid glands through competitive displacing.
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| FDA_UNII_Code |
42255P5X4D
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|
| FULL_SYN |
Perchloric Acid, Potassium Salt Potassium Perchlorate POTASSIUM PERCHLORATE Perchloracap Astrumal
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|
| label |
Potassium Perchlorate
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|
| Legacy Concept Name |
Potassium_Perchlorate
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|
| NSC Number |
41873
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|
| Preferred_Name |
Potassium Perchlorate
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|
| prefixIRI |
Thesaurus:C47681
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0071774
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |