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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47616
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47616
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|---|---|
| Preferred Name | Methyldopa |
| Definitions |
A phenylalanine derivative and an aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This results in a decrease in sympathetic outflow and decreased blood pressure.
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| Synonyms |
3-Hydroxy-alpha-methyl-L-tyrosine
L-2-Amino-2-methyl-3-(3,4-dihydroxyphenyl)propionic Acid
Levo-3-(3,4-Dihydroxyphenyl)-2-methylalanine
Aldomet
Amodopa
Dopamet
METHYLDOPA
Methyldopa
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Methyldopa
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|---|---|
| Legacy Concept Name |
Methyldopa
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| CHEBI_ID |
CHEBI:61058
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| Preferred_Name |
Methyldopa
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| Semantic_Type |
Pharmacologic Substance
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| prefixIRI |
Thesaurus:C47616
|
| DEFINITION |
A phenylalanine derivative and an aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This results in a decrease in sympathetic outflow and decreased blood pressure.
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| UMLS_CUI |
C0025741
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| code |
C47616
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| Chemical_Formula |
2C10H13NO4.3H2O
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| subClassOf | |
| NSC Number |
169916
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| type | |
| CAS_Registry |
41372-08-1
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| FULL_SYN |
3-Hydroxy-alpha-methyl-L-tyrosine
L-2-Amino-2-methyl-3-(3,4-dihydroxyphenyl)propionic Acid
Levo-3-(3,4-Dihydroxyphenyl)-2-methylalanine
Aldomet
Amodopa
Dopamet
METHYLDOPA
Methyldopa
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| FDA_UNII_Code |
56LH93261Y
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| Contributing_Source |
FDA
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| Concept_In_Subset |
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