National Cancer Institute Thesaurus

Last uploaded: June 2, 2026
Id http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47595
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47595
Preferred Name

Mebendazole
Definitions
A synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth. This eventually causes the helminths death.
Synonyms
Methyl 5-benzoyl benzimidazole-2-carbamate
(5-Benzoyl-1H-benzimidazol-2-yl)-carbamic Acid Methyl Ester
MEBENDAZOLE
Mebendazole
R 17635
Vermox
Type http://www.w3.org/2002/07/owl#Class

All Properties

label
Mebendazole
prefixIRI
Thesaurus:C47595
code
C47595
DEFINITION
A synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth. This eventually causes the helminths death.
CHEBI_ID
CHEBI:6704
Legacy Concept Name
Mebendazole
PDQ_Open_Trial_Search_ID
743306
Contributing_Source
CTRP
FDA
NCI_Drug_Dictionary_ID
743306
FULL_SYN
Methyl 5-benzoyl benzimidazole-2-carbamate
(5-Benzoyl-1H-benzimidazol-2-yl)-carbamic Acid Methyl Ester
MEBENDAZOLE
Mebendazole
R 17635
Vermox
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Chemical_Formula
C16H13N3O3
UMLS_CUI
C0025023
FDA_UNII_Code
81G6I5V05I
NSC Number
184849
Preferred_Name
Mebendazole
type
subClassOf
Display_Name
Mebendazole
PDQ_Closed_Trial_Search_ID
743306
CAS_Registry
31431-39-7
Concept_In_Subset
Semantic_Type
Pharmacologic Substance
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