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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Mebendazole | |
| Synonyms |
Methyl 5-benzoyl benzimidazole-2-carbamate (5-Benzoyl-1H-benzimidazol-2-yl)-carbamic Acid Methyl Ester MEBENDAZOLE Mebendazole R 17635 Vermox |
|
| Definitions |
A synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth. This eventually causes the helminths death. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47595 |
|
| CAS_Registry |
31431-39-7
|
|
| CHEBI_ID |
CHEBI:6704
|
|
| Chemical_Formula |
C16H13N3O3
|
|
| code |
C47595
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA
|
|
| DEFINITION |
A synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth. This eventually causes the helminths death.
|
|
| Display_Name |
Mebendazole
|
|
| FDA_UNII_Code |
81G6I5V05I
|
|
| FULL_SYN |
Methyl 5-benzoyl benzimidazole-2-carbamate (5-Benzoyl-1H-benzimidazol-2-yl)-carbamic Acid Methyl Ester MEBENDAZOLE Mebendazole R 17635 Vermox
|
|
| label |
Mebendazole
|
|
| Legacy Concept Name |
Mebendazole
|
|
| NCI_Drug_Dictionary_ID |
743306
|
|
| NSC Number |
184849
|
|
| PDQ_Closed_Trial_Search_ID |
743306
|
|
| PDQ_Open_Trial_Search_ID |
743306
|
|
| Preferred_Name |
Mebendazole
|
|
| prefixIRI |
Thesaurus:C47595
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0025023
|
|
| subClassOf |
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