National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Jump to:
loading...
Preferred Name

Levalbuterol Hydrochloride
Synonyms

(-)-Salbutamol Hydrochloride

1,3-Benzenedimethanol, alpha1-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, Hydrochloride,(alpha1R)-

Levalbuterol Hydrochloride

LEVALBUTEROL HYDROCHLORIDE

Xopenex
Definitions

The hydrochloride salt form of levalbuterol, a relatively selective sympathomimetic beta-2 adrenergic receptor agonist with bronchodilator activity. Levalbuterol hydrochloride binds to beta-2 adrenergic receptors in bronchial smooth muscle and activates intracellular adenyl cyclase, thereby increasing the production of cyclic-3', 5'-adenosine monophosphate (cAMP). Increased cAMP levels lead to the activation of protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular ionic calcium concentrations, resulting in relaxation of bronchial smooth muscles. The increased cyclic AMP concentrations also inhibit the release of inflammatory mediators from mast cells.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47580
CAS_Registry

50293-90-8
Chemical_Formula

C13H21NO3.HCl
code

C47580
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

FDA
DEFINITION

The hydrochloride salt form of levalbuterol, a relatively selective sympathomimetic beta-2 adrenergic receptor agonist with bronchodilator activity. Levalbuterol hydrochloride binds to beta-2 adrenergic receptors in bronchial smooth muscle and activates intracellular adenyl cyclase, thereby increasing the production of cyclic-3', 5'-adenosine monophosphate (cAMP). Increased cAMP levels lead to the activation of protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular ionic calcium concentrations, resulting in relaxation of bronchial smooth muscles. The increased cyclic AMP concentrations also inhibit the release of inflammatory mediators from mast cells.
FDA_UNII_Code

WDQ1526QJM
FULL_SYN

(-)-Salbutamol Hydrochloride

1,3-Benzenedimethanol, alpha1-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, Hydrochloride,(alpha1R)-

Levalbuterol Hydrochloride

LEVALBUTEROL HYDROCHLORIDE

Xopenex
Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74196
label

Levalbuterol Hydrochloride
Legacy Concept Name

Levalbuterol_Hydrochloride
Preferred_Name

Levalbuterol Hydrochloride
prefixIRI

Thesaurus:C47580
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0772502
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48149
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display