National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Diltiazem Malate
Synonyms

DILTIAZEM MALATE

Diltiazem Malate

1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(di-methylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-(2S-cis)-,(S)-hydoxybutanedioate(1:1)

Tiamate
Definitions

A malate salt of diltazem, a benzothiazepine calcium channel blocking agent. Diltiazem inhibits the transmembrane influx of extracellular calcium ions into select myocardial and vascular smooth muscle cells, causing dilatation of coronary and systemic arteries and decreasing myocardial contractility. Because of its vasodilatory activity, this agent has been shown to improve the microcirculation in some tumors, thereby potentially improving the delivery of antineoplastic agents to tumor cells.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47493
CAS_Registry

144604-00-2
Chemical_Formula

C22H26N2O4S.C4H6O5
code

C47493
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

FDA
DEFINITION

A malate salt of diltazem, a benzothiazepine calcium channel blocking agent. Diltiazem inhibits the transmembrane influx of extracellular calcium ions into select myocardial and vascular smooth muscle cells, causing dilatation of coronary and systemic arteries and decreasing myocardial contractility. Because of its vasodilatory activity, this agent has been shown to improve the microcirculation in some tumors, thereby potentially improving the delivery of antineoplastic agents to tumor cells.
FDA_UNII_Code

14Y6444DRP
FULL_SYN

DILTIAZEM MALATE

Diltiazem Malate

1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(di-methylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-(2S-cis)-,(S)-hydoxybutanedioate(1:1)

Tiamate
Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61725
label

Diltiazem Malate
Legacy Concept Name

Diltiazem_Malate
Preferred_Name

Diltiazem Malate
prefixIRI

Thesaurus:C47493
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C1165286
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C333
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