National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Id http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47459
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47459
Preferred Name

Clorazepate Dipotassium

Definitions
A benzodiazepine with anxiolytic, sedative, hypnotic, and anticonvulsant properties. Clorazepate dipotassium exerts its effect by de-activating the nervous system through potentiation of the inhibitory effect of gamma-aminobutyric acid (GABA) on the GABA-A receptors by binding to a site that is distinct from the GABA binding site. Its inhibitory effect is caused by an increase in GABA-mediated chloride channel opening events, leading to hyperpolarization and synaptic inhibition.
Synonyms
1H-1,4-Benzodiazepine-3-carboxylic acid, 7-chloro-2,3-dihydro-2-oxo-5-phenyl-, Monopotassium Salt, compound with Potassium Hydroxide
CLORAZEPATE DIPOTASSIUM
Clorazepate Dipotassium
Potassium 7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylate KOH
Gen-Xene
Tranxene
Type http://www.w3.org/2002/07/owl#Class
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