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National Cancer Institute Thesaurus
| Preferred Name | Chloroprocaine Hydrochloride | |
| Synonyms |
2-Diethylaminoethyl 4-amino-2-chlorobenzoate Hydrochloride Chloroprocaine Hydrochloride CHLOROPROCAINE HYDROCHLORIDE Benzoic Acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl Ester, Hydrochloride Chloroprocaine Nesacaine |
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| Definitions |
A synthetic, aminoester, local, anesthetic agent. At the injection site, chloroprocaine hydrochloride acts by inhibiting sodium influx through binding to specific membrane sodium ion channels in the neuronal cell membranes, restricting sodium permeability, and blocking nerve impulse conduction. This leads to a loss of sensation. Chloroprocaine hydrochloride is short-acting due to rapid hydrolysis by pseudocholinesterase into para-aminobenzoic acid in plasma. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47444 |
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| CAS_Registry |
3858-89-7
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| CHEBI_ID |
CHEBI:3637
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|
| Chemical_Formula |
C13H19ClN2O2.HCl
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|
| code |
C47444
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156952 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159412 |
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| Contributing_Source |
CPTAC FDA
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|
| DEFINITION |
A synthetic, aminoester, local, anesthetic agent. At the injection site, chloroprocaine hydrochloride acts by inhibiting sodium influx through binding to specific membrane sodium ion channels in the neuronal cell membranes, restricting sodium permeability, and blocking nerve impulse conduction. This leads to a loss of sensation. Chloroprocaine hydrochloride is short-acting due to rapid hydrolysis by pseudocholinesterase into para-aminobenzoic acid in plasma.
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| FDA_UNII_Code |
LT7Z1YW11H
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| FULL_SYN |
2-Diethylaminoethyl 4-amino-2-chlorobenzoate Hydrochloride Chloroprocaine Hydrochloride CHLOROPROCAINE HYDROCHLORIDE Benzoic Acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl Ester, Hydrochloride Chloroprocaine Nesacaine
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Chloroprocaine Hydrochloride
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|
| Legacy Concept Name |
Chloroprocaine_Hydrochloride
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| Preferred_Name |
Chloroprocaine Hydrochloride
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| prefixIRI |
Thesaurus:C47444
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0132182
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| subClassOf |
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