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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47386
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47386
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|---|---|
| Preferred Name | Alosetron Hydrochloride |
| Definitions |
The hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system, particularly on enteric and nociceptive sensory neurons, thereby affecting the regulation of visceral pain, decreasing gastrointestinal contraction and motility, and decreasing gastrointestinal secretions. This agent is used to treat diarrhea-predominant irritable bowel syndrome in women.
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| Synonyms |
1H-Pyrido(4,3-b)indol-1-one, 2,3,4,5-tetrahydro-5-methyl-2((5-methyl-1H-imidazol-4-yl)methyl)-, Monohydrochloride
2,3,4,5-Tetrahydro-5-methyl-2-((5-methylimidazol-4-yl)methyl)-1H-pyrido(4,3-b)indol-1-one Monohydrochloride
Alosetron Hydrochloride
ALOSETRON HYDROCHLORIDE
GR 68755c
Lotronex
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label | Alosetron Hydrochloride
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|---|---|
| Legacy Concept Name | Alosetron_Hydrochloride
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| CHEBI_ID | CHEBI:53783
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| Preferred_Name | Alosetron Hydrochloride
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| Semantic_Type | Pharmacologic Substance
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| prefixIRI | Thesaurus:C47386
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| DEFINITION | The hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system, particularly on enteric and nociceptive sensory neurons, thereby affecting the regulation of visceral pain, decreasing gastrointestinal contraction and motility, and decreasing gastrointestinal secretions. This agent is used to treat diarrhea-predominant irritable bowel syndrome in women.
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| UMLS_CUI | C0291771
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| code | C47386
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| Chemical_Formula | C17H18N4O.ClH
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| subClassOf | |
| type | |
| CAS_Registry | 122852-69-1
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| FULL_SYN | 1H-Pyrido(4,3-b)indol-1-one, 2,3,4,5-tetrahydro-5-methyl-2((5-methyl-1H-imidazol-4-yl)methyl)-, Monohydrochloride
2,3,4,5-Tetrahydro-5-methyl-2-((5-methylimidazol-4-yl)methyl)-1H-pyrido(4,3-b)indol-1-one Monohydrochloride
Alosetron Hydrochloride
ALOSETRON HYDROCHLORIDE
GR 68755c
Lotronex
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| FDA_UNII_Code | 2F5R1A46YW
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| Contributing_Source | FDA
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| Concept_In_Subset | |
| Has_Free_Acid_Or_Base_Form |
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