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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47383
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47383
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|---|---|
| Preferred Name | Acrivastine |
| Definitions |
A synthetic alkylamine with non-sedative antihistaminergic activity. Acrivastine competitively blocks the histamine H1 receptor and limits the typical allergic and anaphylactic responses, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contraction of gastrointestinal smooth muscle, caused by actions of histamine on bronchial, and gastrointestinal smooth muscles, and on capillaries. This drug also prevents histamine-induced pain and itching of the skin and mucous membranes. (NCI05)
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| Synonyms |
ACRIVASTINE
(E)-6-((E)-3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)-2-pyridineacrylic Acid
2-Propenoic Acid, 3-(6-(1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-2-pyridinyl)-,(E,E)-
Acrivastine
BW 825C
Semprex
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label | Acrivastine
|
|---|---|
| Legacy Concept Name | Acrivastine
|
| Preferred_Name | Acrivastine
|
| Semantic_Type | Pharmacologic Substance
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| prefixIRI | Thesaurus:C47383
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| DEFINITION | A synthetic alkylamine with non-sedative antihistaminergic activity. Acrivastine competitively blocks the histamine H1 receptor and limits the typical allergic and anaphylactic responses, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contraction of gastrointestinal smooth muscle, caused by actions of histamine on bronchial, and gastrointestinal smooth muscles, and on capillaries. This drug also prevents histamine-induced pain and itching of the skin and mucous membranes. (NCI05)
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| UMLS_CUI | C0054340
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| code | C47383
|
| Chemical_Formula | C22H24N2O2
|
| subClassOf | |
| type | |
| CAS_Registry | 87848-99-5
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| FULL_SYN |
ACRIVASTINE
(E)-6-((E)-3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)-2-pyridineacrylic Acid
2-Propenoic Acid, 3-(6-(1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-2-pyridinyl)-,(E,E)-
Acrivastine
BW 825C
Semprex
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| FDA_UNII_Code | A20F9XAI7W
|
| Contributing_Source | FDA
|
| Concept_In_Subset |
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| Subject | Author | Type | Class | Created |
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| /ontologies/NCIT/notes/https%3A%2F%2Fdata.bioontology.org%2Fnotes%2F8dfd5db0-bd90-0136-3c5b-005056010073 | tabasco_tabata%40yahoo.co.jp | Comment | 2018-10-29 | |
| New concept - total skin sparing mastectomy | anonymous | Comment | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C15277 | 2013-05-22 |
| RE: Antineoplastic antibiotics are antibiotics (?) | rwynne | Comment | 2013-02-13 | |
| Antineoplastic antibiotics are antibiotics (?) | coulet | Comment | 2013-01-25 | |
| Test note | decorons | Comment | 2011-02-07 | |
| New Term Proposal: abcd | fergerson | New Class Proposal | 2010-12-17 | |
| relationship with Smoking Behavior | pkcourtney | Comment | 2010-06-22 | |
| causes and symptoms | linairis | Comment | 2009-08-06 | |
| NIH-What Causes COPD | linairis | Comment | 2009-08-06 | |
| The treatment of COPD | linairis | Comment | 2009-08-06 | |
| MedlinePlus | linairis | Comment | 2009-08-06 | |
| decorons | Comment | 2008-12-31 | ||
| decorons | Comment | 2008-12-31 | ||
| decorons | Comment | 2008-12-31 | ||
| decorons | Comment | 2008-12-31 | ||
| An image example for melanoma | jonquet | Comment | 2008-08-06 | |
| Wikipedia page on 'melanoma' | jonquet | Comment | 2008-08-06 |
Showing 1 to 17 of 17 entries
