National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Id http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C445
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C445
Preferred Name

Dipyridamole
Definitions
A synthetic agent derivative of pyrimido-pyrimidine, with antiplatelet properties. Dipyridamole inhibits adenosine uptake by platelets and endothelial cells, triggering an accumulation of cyclic adenosine monophosphate (cAMP), and inhibiting the stimulation of platelet aggregation by agents such as platelet activating factor and collagen. (NCI04)
Synonyms
DIPYRIDAMOLE
2,2',2'',2''''-[(4,8-Dipiperidinopyrimido-[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol
Dipyridamole
dipyridamole
DP
Persantine
Type http://www.w3.org/2002/07/owl#Class

All Properties

label
Dipyridamole
Legacy Concept Name
Dipyridamole
CHEBI_ID
CHEBI:4653
NCI_Drug_Dictionary_ID
39229
PDQ_Closed_Trial_Search_ID
39229
Preferred_Name
Dipyridamole
Semantic_Type
Organic Chemical
Pharmacologic Substance
prefixIRI
Thesaurus:C445
DEFINITION
A synthetic agent derivative of pyrimido-pyrimidine, with antiplatelet properties. Dipyridamole inhibits adenosine uptake by platelets and endothelial cells, triggering an accumulation of cyclic adenosine monophosphate (cAMP), and inhibiting the stimulation of platelet aggregation by agents such as platelet activating factor and collagen. (NCI04)
UMLS_CUI
C0012582
code
C445
Chemical_Formula
C24H40N8O4
subClassOf
NSC Number
515776
type
CAS_Registry
58-32-2
FULL_SYN
DIPYRIDAMOLE
2,2',2'',2''''-[(4,8-Dipiperidinopyrimido-[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol
Dipyridamole
dipyridamole
DP
Persantine
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FDA_UNII_Code
64ALC7F90C
ALT_DEFINITION
A drug that prevents blood cell clumping and enhances the effectiveness of fluorouracil and other chemotherapeutic agents.
PDQ_Open_Trial_Search_ID
39229
Contributing_Source
FDA
HemOnc
Concept_In_Subset
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