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National Cancer Institute Thesaurus
Last uploaded:
June 2, 2026
| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C436
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C436
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|---|---|
| Preferred Name | Hydromorphone Hydrochloride |
| Definitions |
The hydrochloride salt form of hydromorphone, the hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine monophosphate (cAMP). Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons.
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| Synonyms |
Dilaudid HP
HYDROMORPHONE HYDROCHLORIDE
Hydromorphone Hydrochloride
Hydromorphone
Dilaudid
Dimorphone
Exalgo
Hydrostat
Hymorphan
Laudicon
Novolauden
See more
See less
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label | Hydromorphone Hydrochloride
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|---|---|
| prefixIRI | Thesaurus:C436
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| code | C436
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| DEFINITION | The hydrochloride salt form of hydromorphone, the hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine monophosphate (cAMP). Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons.
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| CHEBI_ID | CHEBI:5791
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| Legacy Concept Name | Hydromorphone
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| PDQ_Open_Trial_Search_ID | 574280
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| Contributing_Source |
CPTAC
FDA
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| Accepted_Therapeutic_Use_For | pain in opioid-tolerant patients.
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| NCI_Drug_Dictionary_ID | 574280
|
| FULL_SYN |
Dilaudid HP
HYDROMORPHONE HYDROCHLORIDE
Hydromorphone Hydrochloride
Hydromorphone
Dilaudid
Dimorphone
Exalgo
Hydrostat
Hymorphan
Laudicon
Novolauden
See more
See less
|
| Chemical_Formula | C17H19NO3.HCl
|
| UMLS_CUI | C0700533
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| FDA_UNII_Code | L960UP2KRW
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| NSC Number | 19046
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| Preferred_Name | Hydromorphone Hydrochloride
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| type | |
| subClassOf | |
| PDQ_Closed_Trial_Search_ID | 574280
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| Has_Free_Acid_Or_Base_Form | |
| CAS_Registry | 71-68-1
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| Concept_In_Subset | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| Delete | Subject | Author | Type | Created |
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