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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C433
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C433
|
|---|---|
| Preferred Name | Diethylstilbestrol |
| Definitions |
A synthetic, nonsteroidal form of estrogen. A well-known teratogen and carcinogen, diethylstilbestrol inhibits the hypothalamic-pituitary-gonadal axis, thereby blocking the testicular synthesis of testosterone, lowering plasma testosterone, and inducing a chemical castration.
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| Synonyms |
Diethylstilbenediol
Diethylstilbestrol
Stilbestrol
4,4'-Dihydroxy-.alpha., .beta.-diethylstilbene
Stilboestroform
Stilboestrol
Oestromensyl
DIETHYLSTILBESTROL
diethylstilbestrol (DES)
.alpha., .alpha.'-Diethylstilbenediol
diethylstilbestrol
Diethylstilboestrol
(E)-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol
3, 4-Bis(p-hydroxyphenyl)-3-hexene
3,4-Bis(p-hydroxyphenyl)-3-hexene
Trans-bis-(hydroxy-4-phenyl)-3,4 hexene-3
4,4'-Dihydroxy-alpha,beta-diethylstilbene
Alpha,alpha'-diethylstilbenediol
3-Hexene,3,4-bis(p-hydroxyphenyl)-
Oestromenin
Synthoestrin
Stilboefral
Neo-Oestronol I
Diethylstilbestrolum
Oestrogenine
Acnestrol
Antigestil
Apstil
Boestrol
Bufon
Cyren A
DES
Diastyl
Distilbene
Domestrol
Estrobene
Estromenin
Estrosyn
Fonatol
Grafestrol
Makarol
Microest
Milestrol
Oestromon
Palestrol
Serral
Sexocretin
Sibol
Stilbetin
Stilkap
Synestrin
Vagestrol
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|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Diethylstilbestrol
|
|---|---|
| Accepted_Therapeutic_Use_For |
Breast cancer; Prostate cancer
|
| Legacy Concept Name |
Diethylstilbestrol
|
| CHEBI_ID |
CHEBI:41922
|
| NCI_Drug_Dictionary_ID |
43081
|
| PDQ_Closed_Trial_Search_ID |
43081
|
| Preferred_Name |
Diethylstilbestrol
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| prefixIRI |
Thesaurus:C433
|
| DEFINITION |
A synthetic, nonsteroidal form of estrogen. A well-known teratogen and carcinogen, diethylstilbestrol inhibits the hypothalamic-pituitary-gonadal axis, thereby blocking the testicular synthesis of testosterone, lowering plasma testosterone, and inducing a chemical castration.
|
| UMLS_CUI |
C0012203
|
| code |
C433
|
| Chemical_Formula |
C18H20O2
|
| subClassOf | |
| NSC Number |
3070
|
| type | |
| CAS_Registry |
56-53-1
|
| FULL_SYN |
Diethylstilbenediol
Diethylstilbestrol
Stilbestrol
4,4'-Dihydroxy-.alpha., .beta.-diethylstilbene
Stilboestroform
Stilboestrol
Oestromensyl
DIETHYLSTILBESTROL
diethylstilbestrol (DES)
.alpha., .alpha.'-Diethylstilbenediol
diethylstilbestrol
Diethylstilboestrol
(E)-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol
3, 4-Bis(p-hydroxyphenyl)-3-hexene
3,4-Bis(p-hydroxyphenyl)-3-hexene
Trans-bis-(hydroxy-4-phenyl)-3,4 hexene-3
4,4'-Dihydroxy-alpha,beta-diethylstilbene
Alpha,alpha'-diethylstilbenediol
3-Hexene,3,4-bis(p-hydroxyphenyl)-
Oestromenin
Synthoestrin
Stilboefral
Neo-Oestronol I
Diethylstilbestrolum
Oestrogenine
Acnestrol
Antigestil
Apstil
Boestrol
Bufon
Cyren A
DES
Diastyl
Distilbene
Domestrol
Estrobene
Estromenin
Estrosyn
Fonatol
Grafestrol
Makarol
Microest
Milestrol
Oestromon
Palestrol
Serral
Sexocretin
Sibol
Stilbetin
Stilkap
Synestrin
Vagestrol
See more
See less
|
| FDA_UNII_Code |
731DCA35BT
|
| ALT_DEFINITION |
A synthetic form of the hormone estrogen that was prescribed to pregnant women between about 1940 and 1971 because it was thought to prevent miscarriages. Diethylstilbestrol may increase the risk of uterine, ovarian, or breast cancer in women who took it. It also has been linked to an increased risk of clear cell carcinoma of the vagina or cervix in daughters exposed to diethylstilbestrol before birth.
|
| PDQ_Open_Trial_Search_ID |
43081
|
| Contributing_Source |
FDA
HemOnc
OORO
|
| Concept_In_Subset |
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