National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Jump to:
Id http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C412
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C412
Preferred Name

Dactinomycin
Definitions
A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. (NCI04)
Synonyms
dactinomycin
Actinomycin-[thr-val-pro-sar-meval]
Lyovac cosmegen
Actinomycin D
Actinomycin I1
ACTINOMYCIN D
Actinomycin C1
Actinomycin IV
DACTINOMYCIN
Lyovac Cosmegen
Actinomycin A IV
Dactinomycin
Dactinomycine
Meractinomycin
Actinomycin X 1
2-bis[Cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3
Cosmegen
DACT
See more
See less
Type http://www.w3.org/2002/07/owl#Class

All Properties

label
Dactinomycin
Is_PCDC_GCT_Authorized_Value_For_Variable
Maps_To
Dactinomycin
Accepted_Therapeutic_Use_For
Wilms' tumor; rhabdomyosarcoma; Ewing's sarcoma; testicular cancer; gestational trophoblastic neoplasia; choriocarcinoma; melanoma; neuroblastoma; retinoblastoma; uterine sarcomas; Kaposi's sarcoma; sarcoma botryoides; soft tissue sarcoma.
Legacy Concept Name
Dactinomycin
CHEBI_ID
CHEBI:27666
NCI_Drug_Dictionary_ID
39675
Is_Value_For_GDC_Property
PDQ_Closed_Trial_Search_ID
39675
Preferred_Name
Dactinomycin
Display_Name
Dactinomycin
Semantic_Type
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Antibiotic
prefixIRI
Thesaurus:C412
DEFINITION
A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. (NCI04)
UMLS_CUI
C0010934
code
C412
Chemical_Formula
C62H86N12O16
subClassOf
NSC Number
3053
type
CAS_Registry
50-76-0
FULL_SYN
dactinomycin
Actinomycin-[thr-val-pro-sar-meval]
Lyovac cosmegen
Actinomycin D
Actinomycin I1
ACTINOMYCIN D
Actinomycin C1
Actinomycin IV
DACTINOMYCIN
Lyovac Cosmegen
Actinomycin A IV
Dactinomycin
Dactinomycine
Meractinomycin
Actinomycin X 1
2-bis[Cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3
Cosmegen
DACT
See more
See less
FDA_UNII_Code
1CC1JFE158
ALT_DEFINITION
An anticancer drug that is a type of antitumor antibiotic.
PDQ_Open_Trial_Search_ID
39675
Contributing_Source
CTRP
FDA
GDC
HemOnc
PCDC
Concept_In_Subset
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display