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National Cancer Institute Thesaurus
| Preferred Name | Cycloleucine | |
| Synonyms |
1-aminocyclopentanecarboxylic acid CYCLOLEUCINE 1-Aminocyclopentanecarboxylic acid 1-Aminocyclopentane Cycloleucine ACP ACPC CB 1639 CB-1639 |
|
| Definitions |
A non-metabolizable synthetic amino acid, formed through the cyclization of the amino acid leucine, with immunosuppressive, antineoplastic, and cytostatic activities. Cycloleucine competitively inhibits the enzyme methionine adenosyltransferase, resulting in the inhibition of S-adenosylmethionine (SAM) synthesis from methionine and ATP, and subsequent nucleic acid methylation and polyamine production; RNA, and perhaps to a lesser extent, DNA biosyntheses and cell cycle progression are finally disrupted. This agent is also a competitive inhibitor at the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C404 |
|
| CAS_Registry |
52-52-8
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|
| Chemical_Formula |
C6H11NO2
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|
| code |
C404
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC
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|
| DEFINITION |
A non-metabolizable synthetic amino acid, formed through the cyclization of the amino acid leucine, with immunosuppressive, antineoplastic, and cytostatic activities. Cycloleucine competitively inhibits the enzyme methionine adenosyltransferase, resulting in the inhibition of S-adenosylmethionine (SAM) synthesis from methionine and ATP, and subsequent nucleic acid methylation and polyamine production; RNA, and perhaps to a lesser extent, DNA biosyntheses and cell cycle progression are finally disrupted. This agent is also a competitive inhibitor at the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor.
|
|
| FDA_UNII_Code |
0TQU7668EI
|
|
| FULL_SYN |
1-aminocyclopentanecarboxylic acid CYCLOLEUCINE 1-Aminocyclopentanecarboxylic acid 1-Aminocyclopentane Cycloleucine ACP ACPC CB 1639 CB-1639
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|
| Is_Value_For_GDC_Property | ||
| label |
Cycloleucine
|
|
| Legacy Concept Name |
Cycloleucine
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|
| Maps_To |
Cycloleucine
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|
| NCI_Drug_Dictionary_ID |
39200
|
|
| NSC Number |
1026
|
|
| PDQ_Closed_Trial_Search_ID |
39200
|
|
| PDQ_Open_Trial_Search_ID |
39200
|
|
| Preferred_Name |
Cycloleucine
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|
| prefixIRI |
Thesaurus:C404
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|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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|
| UMLS_CUI |
C0010575
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| subClassOf |
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