National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Serine/Threonine-Protein Kinase mTOR

Synonyms

Mechanistic Target of Rapamycin

FKBP-Rapamycin Associated Protein

FK506-Binding Protein 12-Rapamycin Complex-Associated Protein 1

Serine/Threonine-Protein Kinase mTOR

FK506 Binding Protein 12-Rapamycin Associated Protein 1

FK506 Binding Protein 12-Rapamycin Associated Protein 2

FKBP12-Rapamycin Complex-Associated Protein

Rapamycin Target Protein

mammalian target of rapamycin

FKBP12 Rapamycin Complex Associated Protein 1

EC 2.7.11.1

Mammalian Target of Rapamycin

Rapamycin Target Protein 1

FRAP

FRAP1

FRAP2

RAFT1

RAPT1

mTOR

Definitions

Serine/threonine-protein kinase mTOR (2549 aa, ~289 kDa) is encoded by the human MTOR gene. This protein is involved in protein phosphorylation, signaling and cell growth.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38929

ALT_DEFINITION

A protein that helps control several cell functions, including cell division and survival, and binds to rapamycin and other drugs. Mammalian target of rapamycin may be more active in some types of cancer cells than it is in normal cells. Blocking mammalian target of rapamycin may cause the cancer cells to die. It is a type of serine/threonine protein kinase.

code

C38929

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142800

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

Contributing_Source

CTRP

DEFINITION

Serine/threonine-protein kinase mTOR (2549 aa, ~289 kDa) is encoded by the human MTOR gene. This protein is involved in protein phosphorylation, signaling and cell growth.

DesignNote

FKBP12-Rapamycin Complex Associated Protein 1 contains 8 HEAT repeats and is a target for the G1 cell-cycle arrest and immunosuppressive effects of FKBP12-rapamycin complex. mTOR regulates ribosome biogenesis and cell growth in response to ATP or nutrient concentrations. FRAP phosphorylation of p53 (inhibited by rapamycin) downregulates PP2A, activates BAX, and induces mitochondrial membrane permeability and caspase activation. Mitogen-induced phospholipase D-dependent phosphatidic acid interacts with the mTOR rapamycin target domain. Cellular stress inhibits MTOR activity by stabilizing MTOR-RAPTOR binding, which also promotes MTOR phosphorylation of 4EBP1 and enhances MTOR activity toward S6K1. MTOR binds UBQLN1.

Display_Name

Serine/Threonine-Protein Kinase mTOR

FULL_SYN

Mechanistic Target of Rapamycin

FKBP-Rapamycin Associated Protein

FK506-Binding Protein 12-Rapamycin Complex-Associated Protein 1

Serine/Threonine-Protein Kinase mTOR

FK506 Binding Protein 12-Rapamycin Associated Protein 1

FK506 Binding Protein 12-Rapamycin Associated Protein 2

FKBP12-Rapamycin Complex-Associated Protein

Rapamycin Target Protein

mammalian target of rapamycin

FKBP12 Rapamycin Complex Associated Protein 1

EC 2.7.11.1

Mammalian Target of Rapamycin

Rapamycin Target Protein 1

FRAP

FRAP1

FRAP2

RAFT1

RAPT1

mTOR

label

Serine/Threonine-Protein Kinase mTOR

Legacy Concept Name

FKBP12-Rapamycin_Complex_Associated_Protein-1

OMIM_Number

601231

Preferred_Name

Serine/Threonine-Protein Kinase mTOR

prefixIRI

Thesaurus:C38929

Semantic_Type

Amino Acid, Peptide, or Protein

Enzyme

Swiss_Prot

P42345

UMLS_CUI

C1307407

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17325

Delete Subject Author Type Created
No notes to display