loading...| Preferred Name |
Adenosine Receptor A2a |
|
| Synonyms |
Adenosine A2 Receptor Adenosine Receptor Subtype A2a Adenosine A2A Receptor Adenosine Receptor A2a Adenosine Receptor Subtype A2A ADORA2 ADORA2A RDC8 hA2aR |
|
| Definitions |
Adenosine receptor A2a (412 aa, ~45 kDa) is encoded by the human ADORA2A gene. This protein plays a role in G protein-coupled receptor signaling, phagocytosis, blood circulation, inflammatory response, sensory perception and central nervous system development |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38612 |
|
| code |
C38612 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 |
|
| Contributing_Source |
CTRP |
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| DEFINITION |
Adenosine receptor A2a (412 aa, ~45 kDa) is encoded by the human ADORA2A gene. This protein plays a role in G protein-coupled receptor signaling, phagocytosis, blood circulation, inflammatory response, sensory perception and central nervous system development |
|
| DesignNote |
Expressed in basal ganglia, vasculature, and platelets by human ADORA2A Gene (GPCR1 Family), 412-aa 45-kDa Adenosine A2A Receptor is a cell-surface integral membrane protein containing 7 transmembrane domains that interacts with a heterotrimeric G protein complex in response to adenosine ligand to stimulate cAMP accumulation through adenylate cyclase activation, is a major target of caffeine, and modulates the activity of various neuronal populations, platelets, neutrophils, and mast cells, and smooth muscle cells in bronchi and vasculature. A potent biologic mediator, most effects of adenosine protect cells during stress. |
|
| Display_Name |
Adenosine Receptor A2a |
|
| FULL_SYN |
Adenosine A2 Receptor Adenosine Receptor Subtype A2a Adenosine A2A Receptor Adenosine Receptor A2a Adenosine Receptor Subtype A2A ADORA2 ADORA2A RDC8 hA2aR |
|
| label |
Adenosine Receptor A2a |
|
| Legacy Concept Name |
Adenosine-A2A_Receptor |
|
| OMIM_Number |
102776 |
|
| Preferred_Name |
Adenosine Receptor A2a |
|
| prefixIRI |
Thesaurus:C38612 |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Receptor |
|
| Swiss_Prot |
P29274 |
|
| UMLS_CUI |
C0255998 |
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| subClassOf |