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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C376
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C376
|
|---|---|
| Preferred Name | Cisplatin |
| Definitions |
An alkylating-like inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition.
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| Synonyms |
Cis-platinum II Diamine Dichloride
(SP-4-2)-Diamminedichloroplatinum
Platinol-AQ VHA Plus
Cis-platinous Diamine Dichloride
Cis-diamminedichloridoplatinum
Peyrone's Chloride
Cis-diammine-dichloroplatinum
Cis-platinum
Citoplatino
Cis-dichloroammine Platinum (II)
Cis-platinum II
Lederplatin
Platinum Diamminodichloride
Cis-diamminedichloroplatinum
Cisplatinum
Platinum, Diaminedichloro-, cis- (8CI)
Platinol- AQ
Cis-diamminedichloro Platinum (II)
Platiblastin
Peyrone's Salt
Platinol-AQ
Platiblastin-S
Abiplatin
Blastolem
Briplatin
CDDP
CISPLATIN
Cismaplat
Cisplatin
Cisplatina
Cisplatyl
Citosin
Cysplatyna
DDP
Metaplatin
Neoplatin
Placis
Plastistil
Platamine
Platinex
Platinol
Platinoxan
Platinum
Platiran
Platistin
Platosin
cisplatin
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|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Cisplatin
|
|---|---|
| Is_PCDC_GCT_Authorized_Value_For_Variable | |
| Maps_To |
Cisplatin
|
| Accepted_Therapeutic_Use_For |
metastatic testicular cancer; ovarian cancer; head and neck cancer; breast cancer; Hodgkin's and non-Hodgkin's lymphoma; myeloma and melanoma
|
| Legacy Concept Name |
Cisplatin
|
| CHEBI_ID |
CHEBI:27899
|
| NCI_Drug_Dictionary_ID |
39515
|
| Is_Value_For_GDC_Property | |
| PDQ_Closed_Trial_Search_ID |
39515
|
| Preferred_Name |
Cisplatin
|
| Display_Name |
Cisplatin
|
| Semantic_Type |
Pharmacologic Substance
Inorganic Chemical
|
| prefixIRI |
Thesaurus:C376
|
| DEFINITION |
An alkylating-like inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition.
|
| UMLS_CUI |
C0008838
|
| code |
C376
|
| Chemical_Formula |
2Cl.Pt.2H3N
|
| subClassOf | |
| NSC Number |
119875
|
| type | |
| CAS_Registry |
15663-27-1
|
| FULL_SYN |
Cis-platinum II Diamine Dichloride
(SP-4-2)-Diamminedichloroplatinum
Platinol-AQ VHA Plus
Cis-platinous Diamine Dichloride
Cis-diamminedichloridoplatinum
Peyrone's Chloride
Cis-diammine-dichloroplatinum
Cis-platinum
Citoplatino
Cis-dichloroammine Platinum (II)
Cis-platinum II
Lederplatin
Platinum Diamminodichloride
Cis-diamminedichloroplatinum
Cisplatinum
Platinum, Diaminedichloro-, cis- (8CI)
Platinol- AQ
Cis-diamminedichloro Platinum (II)
Platiblastin
Peyrone's Salt
Platinol-AQ
Platiblastin-S
Abiplatin
Blastolem
Briplatin
CDDP
CISPLATIN
Cismaplat
Cisplatin
Cisplatina
Cisplatyl
Citosin
Cysplatyna
DDP
Metaplatin
Neoplatin
Placis
Plastistil
Platamine
Platinex
Platinol
Platinoxan
Platinum
Platiran
Platistin
Platosin
cisplatin
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|
| FDA_UNII_Code |
Q20Q21Q62J
|
| ALT_DEFINITION |
A drug used to treat many types of cancer. Cisplatin contains the metal platinum. It kills cancer cells by damaging their DNA and stopping them from dividing. Cisplatin is a type of alkylating agent.
|
| PDQ_Open_Trial_Search_ID |
39515
|
| Contributing_Source |
CTRP
FDA
GDC
HemOnc
PCDC
|
| Concept_In_Subset |
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|
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