National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Cenersen
Synonyms

Aezea

CENERSEN

Cenersen

EL625

OL(1)p53
Definitions

A phosphorothioate oligonucleotide harboring nucleotide sequences complementary to tumor suppressor p53 mRNA. Cenersen hybridizes with p53 mRNA molecules, and induces Rnase H dependent hydrolysis of p53 transcripts in the double stranded section of the hybrids, thereby resulting in loss of p53 production. Loss of p53 activity leads to sensitization of cancer cells to other therapeutics.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C37454
CAS_Registry

415168-49-9
code

C37454
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537
Contributing_Source

CTRP

FDA

GDC
DEFINITION

A phosphorothioate oligonucleotide harboring nucleotide sequences complementary to tumor suppressor p53 mRNA. Cenersen hybridizes with p53 mRNA molecules, and induces Rnase H dependent hydrolysis of p53 transcripts in the double stranded section of the hybrids, thereby resulting in loss of p53 production. Loss of p53 activity leads to sensitization of cancer cells to other therapeutics.
Display_Name

Cenersen
FDA_UNII_Code

K6KJ8AZ05F
FULL_SYN

Aezea

CENERSEN

Cenersen

EL625

OL(1)p53
Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17387
Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909
label

Cenersen
Legacy Concept Name

EL625
Maps_To

Cenersen
NCI_Drug_Dictionary_ID

354249
PDQ_Closed_Trial_Search_ID

354249
PDQ_Open_Trial_Search_ID

354249
Preferred_Name

Cenersen
prefixIRI

Thesaurus:C37454
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0700610
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1291
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