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National Cancer Institute Thesaurus
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February 23, 2024
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Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C362
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C362
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Preferred Name | Chlorambucil |
Definitions |
An orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04)
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Synonyms |
Chlorobutin
N,N-di-2-chloroethyl-gamma-p-aminophenylbutyric acid
CHLORAMBUCIL
Chlorbutine
Chloraminophen
Chloraminophene
gamma-[p-di(2-chloroethyl)aminophenyl]butyric acid
butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl)
chlorambucil
Butyric acid, 4-(p-[bis(2-chloroethyl)amino]phenyl)-
aminochlorambucil
chlorbutinum
Chlorobutine
chloroambucil
Aminochlorambucil
p-N, N-di-(beta-chloroethyl)aminophenyl butyric acid
Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (9CI)
.gamma.-[p-bis(2-chloroethyl)aminophenyl]butyric acid
4-[p-[Bis(2-chloroethyl)amino]phenyl]butyric acid
gamma-(p-bis(2-chloroethyl)aminophenyl)butyric acid
Chlorambucilum
N,N-Di-2-chloroethyl-.gamma.-p-aminophenylbutyric acid
Chlorambucil
.gamma.-[p-Di(2-chloroethyl)aminophenyl]butyric acid
Butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl)-
p-N, N-Di-(.beta.-chloroethyl)aminophenyl butyric acid
4-[bis(2-chloroethyl)amino]benzenebutanoic acid
p-(N, N-di-2-chloroethyl)aminophenyl butyric acid
benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (9CI)
phenylbutyric acid nitrogen mustard
Alti-chlorambucil
Phenylbutyric acid nitrogen mustard
Chloroambucil
p-(N, N-Di-2-chloroethyl)aminophenyl butyric acid
4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid
Ambochlorin
.gamma.-(p-bis(2-chloroethyl)aminophenyl)butyric acid
4-[Bis(2-chloroethyl)amino]benzenebutanoic acid
Lympholysin
Amboclorin
CB 1348
CB-1348
CHL
Chlorbutin
Ecloril
Elcoril
Leukeran
Leukersan
Leukoran
Linfolizin
Linfolysin
WR-139013
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Type | http://www.w3.org/2002/07/owl#Class |
All Properties
label | Chlorambucil
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Maps_To | Chlorambucil
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Accepted_Therapeutic_Use_For | chronic lymphocytic leukemia, Hodgkin lymphoma, and certain types of non-Hodgkin lymphoma.
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Legacy Concept Name | Chlorambucil
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CHEBI_ID | CHEBI:28830
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NCI_Drug_Dictionary_ID | 43113
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Is_Value_For_GDC_Property | |
PDQ_Closed_Trial_Search_ID | 43113
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Preferred_Name | Chlorambucil
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Display_Name | Chlorambucil
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Semantic_Type |
Organic Chemical
Pharmacologic Substance
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prefixIRI | Thesaurus:C362
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DEFINITION | An orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04)
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UMLS_CUI | C0008163
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code | C362
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Chemical_Formula | C14H19Cl2NO2
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subClassOf | |
NSC Number | 3088
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type | |
CAS_Registry | 305-03-3
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FULL_SYN |
Chlorobutin
N,N-di-2-chloroethyl-gamma-p-aminophenylbutyric acid
CHLORAMBUCIL
Chlorbutine
Chloraminophen
Chloraminophene
gamma-[p-di(2-chloroethyl)aminophenyl]butyric acid
butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl)
chlorambucil
Butyric acid, 4-(p-[bis(2-chloroethyl)amino]phenyl)-
aminochlorambucil
chlorbutinum
Chlorobutine
chloroambucil
Aminochlorambucil
p-N, N-di-(beta-chloroethyl)aminophenyl butyric acid
Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (9CI)
.gamma.-[p-bis(2-chloroethyl)aminophenyl]butyric acid
4-[p-[Bis(2-chloroethyl)amino]phenyl]butyric acid
gamma-(p-bis(2-chloroethyl)aminophenyl)butyric acid
Chlorambucilum
N,N-Di-2-chloroethyl-.gamma.-p-aminophenylbutyric acid
Chlorambucil
.gamma.-[p-Di(2-chloroethyl)aminophenyl]butyric acid
Butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl)-
p-N, N-Di-(.beta.-chloroethyl)aminophenyl butyric acid
4-[bis(2-chloroethyl)amino]benzenebutanoic acid
p-(N, N-di-2-chloroethyl)aminophenyl butyric acid
benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (9CI)
phenylbutyric acid nitrogen mustard
Alti-chlorambucil
Phenylbutyric acid nitrogen mustard
Chloroambucil
p-(N, N-Di-2-chloroethyl)aminophenyl butyric acid
4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid
Ambochlorin
.gamma.-(p-bis(2-chloroethyl)aminophenyl)butyric acid
4-[Bis(2-chloroethyl)amino]benzenebutanoic acid
Lympholysin
Amboclorin
CB 1348
CB-1348
CHL
Chlorbutin
Ecloril
Elcoril
Leukeran
Leukersan
Leukoran
Linfolizin
Linfolysin
WR-139013
See more
See less
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FDA_UNII_Code | 18D0SL7309
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ALT_DEFINITION | A drug used to treat several types of leukemias and lymphomas. It blocks cell growth by damaging the cell's DNA and may kill cancer cells. It is a type of alkylating agent.
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PDQ_Open_Trial_Search_ID | 43113
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Contributing_Source |
CTRP
FDA
GDC
HemOnc
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Concept_In_Subset |
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Subject | Author | Type | Class | Created |
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/ontologies/NCIT/notes/https%3A%2F%2Fdata.bioontology.org%2Fnotes%2F8dfd5db0-bd90-0136-3c5b-005056010073 | tabasco_tabata%40yahoo.co.jp | Comment | 2018-10-29 | |
New concept - total skin sparing mastectomy | anonymous | Comment | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C15277 | 2013-05-22 |
RE: Antineoplastic antibiotics are antibiotics (?) | rwynne | Comment | 2013-02-13 | |
Antineoplastic antibiotics are antibiotics (?) | coulet | Comment | 2013-01-25 | |
Test note | decorons | Comment | 2011-02-07 | |
New Term Proposal: abcd | fergerson | New Class Proposal | 2010-12-17 | |
relationship with Smoking Behavior | pkcourtney | Comment | 2010-06-22 | |
causes and symptoms | linairis | Comment | 2009-08-06 | |
NIH-What Causes COPD | linairis | Comment | 2009-08-06 | |
The treatment of COPD | linairis | Comment | 2009-08-06 | |
MedlinePlus | linairis | Comment | 2009-08-06 | |
decorons | Comment | 2008-12-31 | ||
decorons | Comment | 2008-12-31 | ||
decorons | Comment | 2008-12-31 | ||
decorons | Comment | 2008-12-31 | ||
An image example for melanoma | jonquet | Comment | 2008-08-06 | |
Wikipedia page on 'melanoma' | jonquet | Comment | 2008-08-06 |
Showing 1 to 17 of 17 entries
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